通过 N'-(2-炔基苯亚甲基)腙的串联反应合成功能化的 H-吡唑并[5,1-a]异喹啉。
Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazides.
机构信息
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.
出版信息
Org Biomol Chem. 2009 Nov 21;7(22):4641-6. doi: 10.1039/b914265g. Epub 2009 Sep 16.
DOI:10.1039/b914265g
PMID:19865699
Abstract
Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were involved in the transformation.
摘要
通过 N'-(2-炔基苯亚甲基)腙的串联反应，实现了功能化 H-吡唑并[5,1-a]异喹啉的导向多元化合成。该转化涉及溴介导的亲电环化、Ag 催化的炔基亲核加成和钯催化的交叉偶联反应。
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