Norman W H, Brown W A, Miller I W, Keitner G I, Overholser J C
Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island.
Acta Psychiatr Scand. 1990 Feb;81(2):120-5. doi: 10.1111/j.1600-0447.1990.tb06463.x.
The present study was undertaken to further explore the relationship between the dexamethasone suppression test (DST) and suicide. Depressed inpatients who had undergone the DST at index admission and later committed suicide (n = 13) were matched for age, gender, diagnosis, and type of DST (1 mg, 2 mg) with depressed inpatients from the same hospital and study time period to form 2 groups: a suicide attempter group (n = 25) and a nonattempter group (n = 28). The suicide completers group had significantly higher 1600 postdexamethasone cortisol levels than the suicide attempters group and a significantly higher 1600 rate of DST nonsuppression compared with the suicide attempter + nonattempter combined group. Although the rate of DST nonsuppression did not differ between the suicide attempter and nonattempter groups, serious attempters had significantly higher 1600 cortisol levels and a statistically higher proportion of patients who completed suicide than nonserious attempters.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究旨在进一步探讨地塞米松抑制试验（DST）与自杀之间的关系。对在首次入院时接受过DST且后来自杀的抑郁症住院患者（n = 13），按照年龄、性别、诊断和DST类型（1毫克、2毫克）与来自同一医院且处于相同研究时间段的抑郁症住院患者进行匹配，形成两组：自杀未遂组（n = 25）和未未遂组（n = 28）。自杀完成组的地塞米松给药后1600时皮质醇水平显著高于自杀未遂组，与自杀未遂 + 未未遂合并组相比，其DST不抑制率显著更高。尽管自杀未遂组和未未遂组之间的DST不抑制率没有差异，但严重未遂者的地塞米松给药后1600时皮质醇水平显著更高，且完成自杀的患者比例在统计学上高于非严重未遂者。（摘要截断于250字）
