合成并研究了麝香草酚和香芹酚的席夫碱及其抗氧化活性。
Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases.
机构信息
Department of Chemistry, University of Delhi, Delhi 110007, India.
出版信息
Bioorg Med Chem Lett. 2013 Feb 1;23(3):641-5. doi: 10.1016/j.bmcl.2012.12.001. Epub 2012 Dec 8.
Thymol and carvacrol are well known antioxidants found in the extract of the plants of thyme species. The Schiff bases of 2-iso-propyl-5-methyl-phenol (thymol/1a), 2-tert-butyl-5-methyl-phenol (1b) and 5-iso-propyl-2-methyl-phenol (carvacrol/1c) exhibited much better antioxidant activity than thymol and carvacrol in DPPH assay. Ten compounds (4k, 4l, 4r, 5k, 5l, 5q, 5r, 6k, 6l and 6r) showed better or similar activity as compared to the reference compound ascorbic acid. Twenty-four most active compounds were also screened by ABTS method and showed 60-90% inhibition at 5 μg/mL concentration.
百里香酚和香芹酚是从百里香属植物中提取的具有抗氧化性能的物质。2-异丙基-5-甲基苯酚（百里香酚/1a）、2-叔丁基-5-甲基苯酚（1b）和 5-异丙基-2-甲基苯酚（香芹酚/1c）的席夫碱的抗氧化活性明显优于 DPPH 法中的百里香酚和香芹酚。10 种化合物（4k、4l、4r、5k、5l、5q、5r、6k、6l 和 6r）的活性与抗坏血酸相当或优于抗坏血酸。24 种最具活性的化合物还通过 ABTS 法进行了筛选，在 5μg/mL 浓度下的抑制率为 60-90%。
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