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乌氏蜂蜜对扁桃体切除术后愈合过程的促进作用。一项开放标签的前瞻性临床试验。

The effect of Tualang honey in enhancing post tonsillectomy healing process. An open labelled prospective clinical trial.

作者信息

Mat Lazim Norhafiza, Abdullah Baharudin, Salim Rosdan

机构信息

Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan, Malaysia.

出版信息

Int J Pediatr Otorhinolaryngol. 2013 Apr;77(4):457-61. doi: 10.1016/j.ijporl.2012.11.036. Epub 2012 Dec 27.

Abstract

INTRODUCTION

Tonsillectomy is a common operative procedure performed for tonsillar hypertrophy complicates with recurrent tonsillitis. Among the post tonsillectomy morbidities, post operative wound healing is of utmost importance to be effectively managed as it will interfere with patient recuperation from surgery. Tualang honey has been shown to accelerate wound healing in postoperative patients.

OBJECTIVE

The aim of this study was to investigate the effect of Tualang honey in enhancing healing process in post tonsillectomy patients.

METHODOLOGY

In this open labelled prospective study, the selected paediatric patients were randomized into two groups. The 35 subjects in the Tualang honey-antibiotic group received 3 mls of Tualang honey intraoperatively followed by 4 mls of oral Tualang honey three times daily for seven days. Concurrently, 25mg/kg of intravenous Sultamicillin was given three times daily for two days followed by oral Sultamicillin twice daily for five days. The 28 subjects in the antibiotic only group received intravenous at 25mg/kg Sultamicillin kg for two days followed by oral Sultamicillin twice daily for five days. The healing process was assessed at day 1, day 3, day 7 and day 14 postoperatively by semiquantitative endoscopic photograph examination of both tonsillar fossae.

RESULTS

The average ages for the treatment group and the control groups were 9 and 11 years old respectively. Wound healing was significantly faster in the treatment group in both tonsillar fossae compared to the control group (left: p-value = <0.001; right: p-value = <0.001).

CONCLUSION

Tualang honey has positive effect in enhancing healing process in post tonsillectomy patient. It is easy to use topically, safe to consume orally and available at low cost locally. Overall it can be used as an excellent adjunct therapy for post operative patients.

摘要

引言

扁桃体切除术是针对扁桃体肥大并伴有复发性扁桃体炎所施行的常见手术。在扁桃体切除术后的发病情况中,术后伤口愈合对于有效管理极为重要,因为它会影响患者术后的恢复。已证明,乌氏蜂蜜能加速术后患者的伤口愈合。

目的

本研究旨在探讨乌氏蜂蜜对扁桃体切除术后患者愈合过程的影响。

方法

在这项开放标签的前瞻性研究中,将选定的儿科患者随机分为两组。乌氏蜂蜜 - 抗生素组的35名受试者在术中接受3毫升乌氏蜂蜜,随后连续七天每天口服4毫升乌氏蜂蜜,分三次服用。同时,每天静脉注射25毫克/千克的舒他西林,共两天,随后每天口服舒他西林两次,共五天。仅使用抗生素组的28名受试者连续两天静脉注射25毫克/千克的舒他西林,随后每天口服舒他西林两次,共五天。术后第1天、第3天、第7天和第14天,通过对双侧扁桃体窝进行半定量内镜照片检查来评估愈合过程。

结果

治疗组和对照组的平均年龄分别为9岁和11岁。与对照组相比,治疗组双侧扁桃体窝的伤口愈合明显更快(左侧:p值 = <0.001;右侧:p值 = <0.001)。

结论

乌氏蜂蜜对扁桃体切除术后患者的愈合过程有积极作用。它易于局部使用,口服安全,且在当地成本低廉。总体而言,它可作为术后患者的一种出色辅助治疗方法。

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