McLoone Pauline, Oluwadun Afolabi, Warnock Mary, Fyfe Lorna
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Department of Medical Microbiology and Parasitology Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
Cent Asian J Glob Health. 2016 Aug 4;5(1):241. doi: 10.5195/cajgh.2016.241. eCollection 2016.
Problems with conventional treatments for a range of dermatological disorders have led scientists to search for new compounds of therapeutic value. Efforts have included the evaluation of natural products such as honey. Manuka honey, for example, has been scientifically recognised for its anti-microbial and wound healing properties and is now used clinically as a topical treatment for wound infections. In this review, scientific evidence for the effectiveness of honey in the treatment of wounds and other skin conditions is evaluated. A plethora of studies have revealed that honeys from all over the world have potent antimicrobial activity against skin relevant microbes. Moreover, a number of studies suggest that honey is able to modulate the skin immune system. Clinical research has shown honey to be efficacious in promoting the healing of partial thickness burn wounds while its effectiveness in the treatment of non-burn acute wounds and chronic wounds is conflicted. Published research investigating the efficacy of honey in the treatment of other types of skin disorders is limited. Nevertheless, positive effects have been reported, for example, kanuka honey from New Zealand was shown to have therapeutic value in the treatment of rosacea. Anti-carcinogenic effects of honey have also been observed and in a murine model of melanoma. It can be concluded that honey is a biologically active and clinically interesting substance but more research is necessary for a comprehensive understanding of its medicinal value in dermatology.
一系列皮肤病传统治疗方法存在的问题促使科学家寻找具有治疗价值的新化合物。这些努力包括对蜂蜜等天然产物的评估。例如，麦卢卡蜂蜜因其抗菌和伤口愈合特性而得到科学认可，现在临床上用作伤口感染的局部治疗药物。在这篇综述中，对蜂蜜治疗伤口和其他皮肤疾病有效性的科学证据进行了评估。大量研究表明，来自世界各地的蜂蜜对与皮肤相关的微生物具有强大的抗菌活性。此外，一些研究表明蜂蜜能够调节皮肤免疫系统。临床研究表明，蜂蜜在促进浅度烧伤创面愈合方面有效，而其在治疗非烧伤急性伤口和慢性伤口方面的有效性存在争议。已发表的关于蜂蜜治疗其他类型皮肤疾病疗效的研究有限。然而，也有积极效果的报道，例如，新西兰的卡努卡蜂蜜在治疗酒渣鼻方面具有治疗价值。在黑色素瘤小鼠模型中也观察到了蜂蜜的抗癌作用。可以得出结论，蜂蜜是一种具有生物活性且在临床上令人感兴趣的物质，但要全面了解其在皮肤病学中的药用价值，还需要更多研究。
