新型1-烷基-3-羟基-2-甲基吡啶-4-酮螯合剂对巨噬细胞摄取和释放铁的影响。

Effect of novel 1-alkyl-3-hydroxy-2-methylpyrid-4-one chelators on uptake and release of iron from macrophages.

作者信息

Brock J H, Licéaga J, Arthur H M, Kontoghiorghes G J

机构信息

University Department of Bacteriology and Immunology, Western Infirmary, Glasgow, Scotland.

出版信息

Am J Hematol. 1990 May;34(1):21-5. doi: 10.1002/ajh.2830340106.

DOI:10.1002/ajh.2830340106

PMID:2327400

Abstract

The effect of several iron chelators on iron uptake and release by mouse peritoneal macrophages has been investigated. The 1,2-dimethyl (L1) and 1-ethyl-2-methyl (L1NEt) derivatives of 3-hydroxypyrid-4-one markedly enhanced iron mobilisation from macrophages pulsed with 59Fe-transferrin-antitransferrin immune complexes and were more effective than desferrioxamine, maltol, or mimosine. Release increased with increasing chelator concentration. None of the chelators donated significant amounts of iron to macrophages, and none showed any cytotoxic effect. The synthetic alpha-ketohydroxypyridine chelators may therefore be active in removing iron from the reticuloendothelial system as well as from hepatocytes, and indeed may be superior to desferrioxamine.

摘要

研究了几种铁螯合剂对小鼠腹腔巨噬细胞摄取和释放铁的影响。3-羟基吡啶-4-酮的1,2-二甲基（L1）和1-乙基-2-甲基（L1NEt）衍生物显著增强了用59Fe-转铁蛋白-抗转铁蛋白免疫复合物脉冲处理的巨噬细胞中的铁动员，且比去铁胺、麦芽酚或含羞草碱更有效。释放量随螯合剂浓度增加而增加。这些螯合剂均未向巨噬细胞提供大量铁，也均未显示出任何细胞毒性作用。因此，合成的α-酮羟基吡啶螯合剂可能在从网状内皮系统以及肝细胞中去除铁方面具有活性，并且实际上可能优于去铁胺。