Brock J H, Licéaga J, Kontoghiorghes G J
University Department of Bacteriology and Immunology, Western Infirmary, Glasgow, U.K.
FEMS Microbiol Immunol. 1988 Jan;1(1):55-60. doi: 10.1111/j.1574-6968.1988.tb02490.x.
The effect of synthetic iron chelators of the 1-alkyl-3-hydroxy-2-methylpyrid-4-one class (the L1 series) and 1-hydroxypyrid-2-one (L4) on bacterial growth in human serum was compared with those of the plant iron chelators mimosine and maltol and of the microbial siderophore desferrioxamine. None of the synthetic chelators enhanced growth of 3 Gram-negative organisms (Yersinia enterocolitica, Escherichia coli and Pseudomonas aeruginosa); in some cases they were even inhibitory. L4 strongly stimulated growth of Staphylococcus epidermidis, but the L1 series had only a marginal effect. Maltol was mildly inhibitory to all 4 bacterial species, while mimosine enhanced the growth of S. epidermidis and Y. enterocolitica but had little effect on E. coli or P. aeruginosa. Desferrioxamine enhanced the growth of all except E. coli. These results suggest that the chelators of synthetic or plant origin may carry less risk of increasing susceptibility to bacterial infection in patients undergoing chelation therapy for iron overload than does desferrioxamine, the drug currently in clinical use.
将1-烷基-3-羟基-2-甲基吡啶-4-酮类（L1系列）和1-羟基吡啶-2-酮（L4）的合成铁螯合剂对人血清中细菌生长的影响，与植物铁螯合剂含羞草碱和麦芽酚以及微生物铁载体去铁胺的影响进行了比较。合成螯合剂均未促进3种革兰氏阴性菌（小肠结肠炎耶尔森菌、大肠杆菌和铜绿假单胞菌）的生长；在某些情况下，它们甚至具有抑制作用。L4强烈刺激表皮葡萄球菌的生长，但L1系列只有轻微作用。麦芽酚对所有4种细菌均有轻微抑制作用，而含羞草碱可促进表皮葡萄球菌和小肠结肠炎耶尔森菌的生长，但对大肠杆菌或铜绿假单胞菌几乎没有影响。去铁胺可促进除大肠杆菌外所有细菌的生长。这些结果表明，与目前临床使用的药物去铁胺相比，合成或植物来源的螯合剂在对铁过载进行螯合治疗的患者中，增加细菌感染易感性的风险可能更低。
