Tilly H, Azagury M, Bastit D, Lallemand A, Piguet H
Service d'Hématologie, Centre Henri Becquerel, Rouen, France.
Am J Hematol. 1990 May;34(1):75-6. doi: 10.1002/ajh.2830340118.
We describe a 16-year-old girl with aplastic anemia who, 1 year after initial diagnosis developed a refractory state to platelet transfusions due to alloimmunization and resulting in severe bleeding. Treatment with cyclosporin, initially prescribed as treatment of the bone marrow failure, resulted in prompt decrease in lymphocytotoxic antibodies, which paralleled a marked improvement in platelet recovery. To our knowledge, such a dramatic effect of cyclosporin on alloimmunization has not been previously reported and merits further attention.
我们描述了一名16岁再生障碍性贫血女孩，在初次诊断1年后，由于同种免疫对血小板输注产生难治状态，导致严重出血。最初作为骨髓衰竭治疗而开具的环孢素治疗，使淋巴细胞毒性抗体迅速减少，这与血小板恢复的显著改善同时出现。据我们所知，环孢素对同种免疫的这种显著效果此前尚未见报道，值得进一步关注。
