一种方便且高度立体选择性的合成八氢吡咯并[3,2-b]吡咯衍生物的方法。
A convenient and highly stereoselective method for synthesis of octahydropyrano[3,2-b]pyrrole derivatives.
机构信息
Natural Product Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China.
出版信息
Carbohydr Res. 2013 Jan 25;366:55-62. doi: 10.1016/j.carres.2012.11.016. Epub 2012 Nov 29.
PMID:23274359
Abstract
The octahydropyrano[3,2-b]pyrrole derivatives are synthesized by a double reductive amination from pyranose derivatives of nono-2,5-diuloses and octos-4-uloses and various amines. The cyclization proceeded smoothly in the presence of sodium triacetoxyborohydride to produce a series of novel fused N-heterobicyclic compounds with high stereoselectivity.
摘要
八氢吡咯并[3,2-b]吡咯衍生物是通过来自壬糖衍生物的非 2,5-二醛和辛糖-4-醛以及各种胺的双重还原胺化反应合成的。在三乙酰氧基硼氢化钠的存在下，环化反应顺利进行，生成了一系列具有高立体选择性的新型稠合 N-杂双环化合物。
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