Program of Genomics, Department of Veterinary Microbiology and Pathology, Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Exp Parasitol. 2013 Mar;133(3):365-8. doi: 10.1016/j.exppara.2012.12.013. Epub 2012 Dec 26.
Babesiosis, a significant veterinary disease and an emerging zoonotic human infection, is caused by certain species of the protozoan parasite, Babesia. Here we report that a trisubstituted pyrrole is a potent inhibitor of Babesia bovis, a bovine parasite. Furthermore, B. bovis expresses the known target of the compound, the cGMP dependent protein kinase. Target conservation and the in vitro efficacy support further investigation of this compound and validation of Babesia cGMP dependent protein kinase as its in vivo target.
巴贝斯虫病是一种重要的兽医疾病，也是一种新兴的人畜共患感染病，由原生动物寄生虫巴贝斯虫的某些物种引起。在这里，我们报告说，三取代吡咯是一种有效的牛巴贝斯虫抑制剂，牛巴贝斯虫是一种牛寄生虫。此外，牛巴贝斯虫表达了该化合物的已知靶标，即 cGMP 依赖性蛋白激酶。靶标保守性和体外功效支持对该化合物的进一步研究，并验证 Babesia cGMP 依赖性蛋白激酶作为其体内靶标。
