N-乙酰-L-半胱氨酸对巴贝斯虫和泰勒虫寄生虫抑制作用的评估。
Evaluation of the inhibitory effect of N-acetyl-L-cysteine on Babesia and Theileria parasites.
作者信息
Rizk Mohamed Abdo, El-Sayed Shimaa Abd El-Salam, AbouLaila Mahmoud, Yokoyama Naoaki, Igarashi Ikuo
机构信息
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan; Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan; Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
出版信息
Exp Parasitol. 2017 Aug;179:43-48. doi: 10.1016/j.exppara.2017.06.003. Epub 2017 Jun 24.
N-acetyl-L-cysteine is known to have antibacterial, antiviral, antimalarial, and antioxidant activities. Therefore, the in vitro inhibitory effect of this hit was evaluated in the present study on the growth of Babesia and Theileria parasites. The in vitro growth of Babesia bovis, Babesia bigemina, Babesia divergens, Theileria equi, and Babesia caballi that were tested was significantly inhibited (P < 0.05) by micromolar concentrations of N-acetyl-L-cysteine. The inhibitory effect of N-acetyl-L-cysteine was synergistically potentiated when used in combination with diminazene aceturate on B. bovis and B. caballi cultures. These results indicate that N-acetyl-L-cysteine might be used as a drug for the treatment of babesiosis, especially when used in combination with diminazene aceturate.
已知N-乙酰-L-半胱氨酸具有抗菌、抗病毒、抗疟疾和抗氧化活性。因此，本研究评估了该活性成分对巴贝斯虫和泰勒虫寄生虫生长的体外抑制作用。所测试的牛巴贝斯虫、双芽巴贝斯虫、分歧巴贝斯虫、马泰勒虫和驽巴贝斯虫的体外生长受到微摩尔浓度的N-乙酰-L-半胱氨酸的显著抑制（P<0.05）。当N-乙酰-L-半胱氨酸与乙酰氨基阿维菌素联合用于牛巴贝斯虫和驽巴贝斯虫培养时，其抑制作用具有协同增强效果。这些结果表明，N-乙酰-L-半胱氨酸可能用作治疗巴贝斯虫病的药物，尤其是与乙酰氨基阿维菌素联合使用时。
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