遗传多态性与 45 岁以下心肌梗死患者的风险。
Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.
机构信息
Department of Medical Biotechnology, Medical University of Lodz, Zeligowskiego 7/9, 90-725, Lodz, Poland.
出版信息
Biochem Genet. 2013 Apr;51(3-4):230-42. doi: 10.1007/s10528-012-9558-5. Epub 2012 Dec 30.
Abstract
This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed using the PCR-RFLP method. Of the chosen polymorphisms, two (Leu125Val PECAM1 and A1/A2 FVII) are related to myocardial infarction and two (C677T MTHFR and 5A/6A MMP3) to advanced stenosis in arterial vessels (> 75%). We also found that the frequency of some combinations among the analyzed genes and environmental factors varied between the patient and control groups.
摘要
本研究调查了 15 个候选基因中 17 个选定的多态性在 45 岁以下心肌梗死患者中的潜在作用和风险。该研究包括 271 名心肌梗死患者和 141 名对照。遗传多态性分析采用 PCR-RFLP 方法进行。在所选择的多态性中，两个（PECAM1 的 Leu125Val 和 FVII 的 A1/A2）与心肌梗死有关，两个（MTHFR 的 C677T 和 MMP3 的 5A/6A）与动脉血管的严重狭窄（>75%）有关。我们还发现，在分析的基因和环境因素之间的一些组合在患者和对照组之间存在差异。
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