Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Metabolism. 2012 Jun;61(6):846-52. doi: 10.1016/j.metabol.2011.10.013. Epub 2011 Dec 5.
Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism has been suggested to be associated with increased coronary artery disease (CAD) risk. To explore the relationship between MTHFR C677T gene polymorphism and CAD in the Chinese Han population, a meta-analysis was performed. Fourteen separate studies were included and 2981 subjects were involved in the current meta-analysis. The pooled odds ratio (OR) between CAD size to CAD size and control size (CAD/CAD + control) and the corresponding 95% confidence interval (95% CI) between the CC and TT genotype groups were estimated by a random-effects model. Meta-regression was performed to explore the heterogeneity source. The CAD/CAD + control values were 0.45 for the CC genotype group and 0.62 for the TT genotype group. The pooled OR for the CAD/CAD + control between the CC and TT genotype groups was 0.55 (95% CI, 0.37-0.83; P(heterogeneity) = .0004, I(2) = 64.7%). These results indicated that MTHFR C677T gene polymorphism and CAD were significantly associated (P = .005) in the Chinese Han population. Publication year was detected as the main heterogeneity source. In a stratified analysis by publication year, the pooled OR was 0.76 (95% CI, 0.37-1.57; P(heterogeneity) = .0002; I(2) = 79.6%) in subgroup 1 (publication years 1999-2004). No significant association between gene polymorphism and CAD was found in this subgroup (P = .46). In subgroup 2 (publication years 2005-2011), the pooled OR was 0.39 (95% CI, 0.28-0.55; P(heterogeneity) = .53; I(2) = 0); and the association between gene polymorphism and CAD was significant (P < .00001). In the Chinese Han population, the TT genotype for the MTHFR C677T gene appeared to be associated with increased CAD risk.
亚甲基四氢叶酸还原酶（MTHFR）C677T 基因多态性与冠心病（CAD）风险增加有关。为了探讨中国汉族人群中 MTHFR C677T 基因多态性与 CAD 的关系，进行了一项荟萃分析。纳入了 14 项独立研究，共有 2981 例受试者纳入本次荟萃分析。采用随机效应模型估计 CAD 大小与 CAD 大小和对照组大小（CAD/CAD+对照组）之间的合并优势比（OR），以及 CC 和 TT 基因型组之间的相应 95%置信区间（95%CI）。进行荟萃回归以探讨异质性来源。CC 基因型组的 CAD/CAD+对照组值为 0.45，TT 基因型组为 0.62。CC 和 TT 基因型组之间 CAD/CAD+对照组的合并 OR 为 0.55（95%CI，0.37-0.83；P（异质性）=0.0004，I²=64.7%）。这些结果表明，MTHFR C677T 基因多态性与 CAD 在中国汉族人群中显著相关（P=0.005）。发表年份被检测为主要异质性来源。按发表年份进行分层分析时，亚组 1（发表年份 1999-2004 年）的合并 OR 为 0.76（95%CI，0.37-1.57；P（异质性）=0.0002；I²=79.6%）。在该亚组中，基因多态性与 CAD 之间无显著相关性（P=0.46）。在亚组 2（发表年份 2005-2011 年）中，合并 OR 为 0.39（95%CI，0.28-0.55；P（异质性）=0.53；I²=0），基因多态性与 CAD 之间的相关性显著（P<0.00001）。在中国汉族人群中，MTHFR C677T 基因的 TT 基因型似乎与 CAD 风险增加有关。
