Section of Respiratory Diseases, Department of Oncology, Haematology & Pulmonology, University of Modena and Reggio Emilia, Modena, Italy.
Lung Cancer. 2013 Mar;79(3):294-9. doi: 10.1016/j.lungcan.2012.11.024. Epub 2012 Dec 28.
Clusterin expression may change in various human malignancies, including lung cancer. Patients with resectable non-small cell lung cancer (NSCLC), including adenocarcinoma, have a poor prognosis, with a relapse rate of 30-50% within 5 years. Nuclear factor kB (Nf-kB) is an intracellular protein involved in the initiation and progression of several human cancers, including the lung.
We investigate the role of clusterin and Nf-kB expression in predicting the prognosis of patients with early-stage surgically resected adenocarcinoma of the lung.
The level of clusterin gradually decreased from well-differentiated to poorly differentiated adenocarcinomas. Clusterin expression was significantly higher in patients with low-grade adenocarcinoma, in early-stage disease and in women. Clusterin expression was inversely related to relapse and survival in both univariate and multivariate analyses. Finally, we observed an inverse correlation between Nf-kB and clusterin.
Clusterin expression represents an independent prognostic factor in surgically resected lung adenocarcinoma and was proven to be a useful biomarker for fewer relapses and longer survival in patients in the early stage of disease. The inverse correlation between Nf-kB and clusterin expression confirm the previously reported role of clusterin as potent down regulator of Nf-kB.
簇集蛋白的表达可能在各种人类恶性肿瘤中发生改变，包括肺癌。可切除的非小细胞肺癌（NSCLC）患者，包括腺癌，预后不良，5 年内复发率为 30-50%。核因子 kB（Nf-kB）是一种参与多种人类癌症，包括肺癌的起始和进展的细胞内蛋白。
我们研究簇集蛋白和 Nf-kB 表达在预测早期手术切除的肺腺癌患者预后中的作用。
簇集蛋白的水平从高分化腺癌逐渐降低到低分化腺癌。低级别腺癌、早期疾病和女性患者的簇集蛋白表达明显更高。在单变量和多变量分析中，簇集蛋白表达与复发和生存呈负相关。最后，我们观察到 Nf-kB 与簇集蛋白之间存在负相关。
簇集蛋白的表达是手术切除的肺腺癌的独立预后因素，并且被证明是疾病早期患者复发率较低和生存时间较长的有用生物标志物。Nf-kB 和簇集蛋白表达之间的负相关证实了簇集蛋白作为 Nf-kB 有效抑制剂的先前报道作用。
