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肯尼亚基苏木一项艾滋病毒发病率队列研究的基线结果,为未来的艾滋病毒预防临床试验做准备。

Baseline findings of an HIV incidence cohort study to prepare for future HIV prevention clinical trials in Kisumu, Kenya.

作者信息

Chege Wairimu, Pals Sherri L, McLellan-Lemal Eleanor, Shinde Sanjyot, Nyambura Monicah, Otieno Frederick O, Gust Deborah A, Chen Robert T, Thomas Timothy

机构信息

Centers for Disease Control and Prevention (CDC), Division of HIV/AIDS Prevention, Atlanta, USA.

出版信息

J Infect Dev Ctries. 2012 Dec 15;6(12):870-80. doi: 10.3855/jidc.2636.

DOI:10.3855/jidc.2636
PMID:23276741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6066670/
Abstract

INTRODUCTION

In an analysis of baseline findings of an HIV incidence cohort study, an assessment was made of HIV prevalence among persons presenting for enrollment and any differences in demographic characteristics between persons not enrolled compared to those enrolled. We also described and compared HIV risk behaviors in males and females enrolled in the study.

METHODOLOGY

A computer-assisted survey was administered to collect baseline demographic and HIV risk data from 1,277 men and women aged 18-34 years. Testing for HIV and other sexually transmitted infections (STI) was conducted. Out of 1,277 persons prescreened for eligibility, 625 were enrolled.

RESULTS

HIV prevalence of all persons who completed screening was 14.8% (females: 21.1%; males: 8.1%). The odds of being enrolled in the study were higher for persons 18-24 years compared to those 30-34 years of age [adjusted odds ratio (AOR)=2.18, CI=1.13, 4.21] and males compared to females [AOR=2.07, CI=1.43, 2.99]. Among those enrolled in the study, the most prevalent HIV risk behaviors were unprotected sex (49%), alcohol use (45%), and transactional sex (30%) in the last three months. Compared to females, a significantly greater proportion of males reported using any alcohol or recreational drug in the last three months, a history of oral sex, sex with partner other than a spouse or main partner, ever having a blood transfusion, ever being treated for an STI, and having knowledge of their last HIV test result.

CONCLUSION

The Kisumu Field Station successfully recruited individuals with HIV risk characteristics for the HIV incidence cohort study.

摘要

引言

在一项HIV发病率队列研究的基线结果分析中,对报名参加者中的HIV流行情况以及未报名者与已报名者在人口统计学特征上的差异进行了评估。我们还描述并比较了该研究中男性和女性的HIV风险行为。

方法

采用计算机辅助调查,收集了1277名年龄在18至34岁之间的男性和女性的基线人口统计学及HIV风险数据。进行了HIV及其他性传播感染(STI)检测。在1277名预先筛查是否符合条件的人员中,625人被纳入研究。

结果

所有完成筛查的人员中,HIV流行率为14.8%(女性:21.1%;男性:8.1%)。18至24岁的人员被纳入研究的几率高于30至34岁的人员[调整优势比(AOR)=2.18,可信区间(CI)=1.13,4.21],男性被纳入研究的几率高于女性[AOR=2.07,CI=1.43,2.99]。在纳入研究的人员中,过去三个月中最常见的HIV风险行为是无保护性行为(49%)、饮酒(45%)和交易性行为(30%)。与女性相比,在过去三个月中报告使用过任何酒精或娱乐性药物、有口交史、与配偶或主要伴侣以外的人发生性行为、曾接受输血、曾接受STI治疗以及知晓其上次HIV检测结果的男性比例显著更高。

结论

基苏木实地研究站成功招募了具有HIV风险特征的个体参与HIV发病率队列研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0e/6066670/b7d5ff34e609/nihms808376f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0e/6066670/b7d5ff34e609/nihms808376f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0e/6066670/b7d5ff34e609/nihms808376f1.jpg

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