Elder J, McLelland A, O'Reilly D S, Packard C J, Series J J, Shepherd J
Institute of Biochemistry, Royal Infirmary, Glasgow, Scotland.
Ann Clin Biochem. 1990 Mar;27 ( Pt 2):110-3. doi: 10.1177/000456329002700204.
The relationship between serum cholesterol, thyrotropin, thyroxine and tri-iodothyronine was investigated in 1018 female patients over 40 years of age with suspected hypothyroidism. The correlation between serum thyrotropin and cholesterol (r = 0.398) and between thyroxine and cholesterol (r = -0.217) were both highly significant (P less than 0.001), but the correlation between tri-iodothyronine and cholesterol (r = -0.011) was not significant. Only in patients with a serum thyrotropin in excess of 40 mU/L was there a clinically appreciable increase in the serum cholesterol. In 139 patients treated for hypothyroidism by thyroxine replacement there was a highly significant correlation (P less than 0.001) between the decrease in serum thyrotropin and cholesterol (r = 0.593). The correlation between increase in serum thyroxine and decrease in cholesterol (r = -0.401) was also highly significant (P less than 0.001), but there was an even stronger correlation between the increase in serum tri-iodothyronine and the decrease in serum cholesterol (r = -0.529).
对1018名40岁以上疑似甲状腺功能减退的女性患者的血清胆固醇、促甲状腺激素、甲状腺素和三碘甲状腺原氨酸之间的关系进行了研究。血清促甲状腺激素与胆固醇之间的相关性（r = 0.398）以及甲状腺素与胆固醇之间的相关性（r = -0.217）均高度显著（P < 0.001），但三碘甲状腺原氨酸与胆固醇之间的相关性（r = -0.011）不显著。仅在血清促甲状腺激素超过40 mU/L的患者中，血清胆固醇才有临床上可察觉的升高。在139例接受甲状腺素替代治疗甲状腺功能减退的患者中，血清促甲状腺激素降低与胆固醇降低之间存在高度显著的相关性（P < 0.001）（r = 0.593）。血清甲状腺素升高与胆固醇降低之间的相关性（r = -0.401）也高度显著（P < 0.001），但血清三碘甲状腺原氨酸升高与血清胆固醇降低之间的相关性更强（r = -0.529）。
