Andersen Consulting, 424 Granite Lake Ct, Denver, NC 28037, USA.
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd - MS 1018, Kansas City, KS 66160, USA.
Toxicology. 2021 Jul;459:152845. doi: 10.1016/j.tox.2021.152845. Epub 2021 Jul 8.
Serum concentrations of cholesterol are positively correlated with exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) in humans. The associated change in cholesterol is small across a broad range of exposure to PFOA and PFOS. Animal studies generally have not indicated a mechanism that would account for the association in humans. The extent to which the relationship is causal is an open question. Nonetheless, the association is of particular importance because increased serum cholesterol has been considered as an endpoint to derive a point of departure in at least one recent risk assessment. To gain insight into potential mechanisms for the association, both causal and non-causal, an expert workshop was held Oct 31 and Nov 1, 2019 to discuss relevant data and propose new studies. In this report, we summarize the relevant background data, the discussion among the attendees, and their recommendations for further research.
血清胆固醇浓度与人体内全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）的暴露呈正相关。在广泛的 PFOA 和 PFOS 暴露范围内，胆固醇的变化很小。动物研究通常没有表明一种可以解释人类这种关联的机制。这种关系在多大程度上是因果关系是一个悬而未决的问题。尽管如此，这种关联尤其重要，因为在最近的至少一次风险评估中，血清胆固醇升高已被认为是一个起始点的终点。为了深入了解这种关联的潜在机制，包括因果关系和非因果关系，于 2019 年 10 月 31 日和 11 月 1 日举行了一次专家研讨会，以讨论相关数据并提出新的研究建议。在本报告中，我们总结了相关背景数据、与会者的讨论以及他们对进一步研究的建议。
