恒河猴口服多西环素的药代动力学分析。
Pharmacokinetic analysis of oral doxycycline in rhesus macaques.
作者信息
Embers Monica E, Hasenkampf Nicole R, Embers Dale G, Doyle Lara A
机构信息
Division of Bacteriology & Parasitology, Tulane National Primate Research Center, Covington, LA 70433, USA.
出版信息
J Med Primatol. 2013 Apr;42(2):57-61. doi: 10.1111/jmp.12031. Epub 2012 Dec 20.
BACKGROUND
Following administration of an antibiotic, the concentration in blood changes over time and is dependent on the type of antibiotic, the route and species of the individual. The most relevant pharmacodynamic property of a bacteriostatic antibiotic such as doxycycline is the minimum inhibitory concentration (MIC), whereas pharmacokinetics may include rates of absorption and elimination from blood.
METHODS
We determined serum concentrations of doxycycline following administration of 5 mg/kg in two macaques.
RESULTS
The area under the concentration-time curve over 24 hours (AUC0-24 ) following two doses was extrapolated from the curve over 12 hours following a single dose, with the purpose of calculating the AUC0-24 :MIC.
CONCLUSIONS
Other than a somewhat faster rate of elimination, the PK-PD values for doxycycline in macaques appears similar to those determined for humans. This information will be valuable for treating disease in macaques and for research in bacterial infection models that use macaques.
背景
给予抗生素后，血液中的浓度会随时间变化，且取决于抗生素的类型、给药途径以及个体的物种。像强力霉素这样的抑菌性抗生素，其最相关的药效学特性是最低抑菌浓度（MIC），而药代动力学可能包括从血液中的吸收和消除速率。
方法
我们测定了两只猕猴给予5mg/kg强力霉素后的血清浓度。
结果
两剂后24小时浓度-时间曲线下面积（AUC0-24）是根据单剂后12小时的曲线外推得出的，目的是计算AUC0-24:MIC。
结论
除了消除速率稍快外，猕猴体内强力霉素的药代动力学-药效学值似乎与人类测定的值相似。这些信息对于治疗猕猴疾病以及在使用猕猴的细菌感染模型研究中将具有重要价值。
Zotero 插件