慢性心力衰竭大鼠心率外周迷走神经控制的高频优势抑制。
High-frequency dominant depression of peripheral vagal control of heart rate in rats with chronic heart failure.
机构信息
Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.
出版信息
Acta Physiol (Oxf). 2013 Mar;207(3):494-502. doi: 10.1111/apha.12055. Epub 2013 Jan 18.
AIM
To examine whether dynamic characteristics of the peripheral vagal control of heart rate (HR) are altered in chronic heart failure (CHF).
METHODS
The right vagal nerve was electrically stimulated according to a binary white noise signal, and the transfer function from vagal nerve stimulation (VNS) to HR was estimated in the frequency range from 0.01 to 1 Hz in five control rats and five CHF rats under anaesthetized conditions. The rate of VNS was changed among 10, 20 and 40 Hz.
RESULTS
A multiple linear regression analysis indicated that the increase in the VNS rate augmented the ratio of the high-frequency (HF) gain to the steady-state gain in the control group but not in the CHF group. As a result, the dynamic gain of the transfer function in the frequencies near 1 Hz decreased more in the CHF group than in the control group.
CONCLUSION
Changes in the dynamic characteristics of the peripheral vagal control of HR may contribute to the manifestation of decreased HF components of HR variability observed in CHF.
目的
观察慢性心力衰竭（CHF）患者心率（HR）外周迷走神经控制的动态特征是否改变。
方法
在麻醉状态下，用电刺激右侧迷走神经，根据二进制白噪声信号，对 5 只正常大鼠和 5 只 CHF 大鼠的迷走神经刺激（VNS）与 HR 之间的传递函数进行了频率范围在 0.01 至 1 Hz 的估计。VNS 的频率在 10、20 和 40 Hz 之间变化。
结果
多元线性回归分析表明，VNS 率的增加增强了对照组高频（HF）增益与稳态增益的比值，但 CHF 组没有。因此，CHF 组在 1 Hz 左右的频率上，传递函数的动态增益下降幅度大于对照组。
结论
HR 外周迷走神经控制的动态特征的变化可能导致 CHF 中观察到的 HR 变异性高频（HF）成分减少。
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