Agarwal Rahul, Mokelke Eric, Ruble Stephen B, Stolen Craig M
Boston Scientific Corporation, 4100 Hamline Ave. North, St. Paul, MN, 55112, USA.
J Cardiovasc Transl Res. 2016 Feb;9(1):67-76. doi: 10.1007/s12265-015-9668-7. Epub 2016 Jan 8.
This study investigated whether vagal nerve stimulation (VNS) leads to improvements in ischemic heart failure via heart rate modulation. At 7 ± 1 days post left anterior descending artery (LAD) ligation, 63 rats with myocardial infarctions (MI) were implanted with ECG transmitters and VNS devices (MI + VNS, N = 44) or just ECG transmitters (MI, N = 17). VNS stimulation was active from 14 ± 1 days to 8 ± 1 weeks post MI. The average left ventricular (LV) end diastolic volumes at 8 ± 1 weeks were MI = 672.40 μl and MI + VNS = 519.35 μl, p = 0.03. The average heart weights, normalized to body weight (± std) at 14 ± 1 weeks were MI = 3.2 ± 0.6 gkg(-1) and MI + VNS = 2.9 ± 0.3 gkg(-1), p = 0.03. The degree of cardiac remodeling was correlated with the magnitude of acute VNS-evoked heart rate (HR) changes. Further research is required to determine if the acute heart rate response to VNS activation is useful as a heart failure biomarker or as a tool for VNS therapy characterization.
本研究调查了迷走神经刺激（VNS）是否通过心率调节改善缺血性心力衰竭。在左冠状动脉前降支（LAD）结扎术后7±1天，将63只心肌梗死（MI）大鼠植入心电图发射器和VNS装置（MI + VNS，N = 44）或仅植入心电图发射器（MI，N = 17）。VNS刺激在心肌梗死后14±1天至8±1周期间激活。在8±1周时，平均左心室（LV）舒张末期容积分别为：MI组672.40μl，MI + VNS组519.35μl，p = 0.03。在14±1周时，平均心脏重量（以体重标准化，±标准差）分别为：MI组3.2±0.6 gkg(-1)，MI + VNS组2.9±0.3 gkg(-1)，p = 0.03。心脏重塑程度与急性VNS诱发的心率（HR）变化幅度相关。需要进一步研究以确定VNS激活引起的急性心率反应是否可作为心力衰竭生物标志物或用于VNS治疗特征描述的工具。
