Wold J S, Turnipseed S A
Drug Metab Dispos. 1978 Jan-Feb;6(1):87-90.
The accumulation of cephaloridine in the renal cortex of the rabbit was studied in vitro and in vivo in rabbits of various ages. The cortical concentration of cephaloridine, the cortex/serum ratio, and the slice/medium ratio determined by incubation of cortical slices in cephaloridine-containing media rose from birth to adult levels at approximately 1 month of age. Pretreatment with procaine penicillin G stimulated the ability to accumulate cephaloridine in vitro and in vivo. The data indicate that the lack of susceptibility of immature rabbits to cephaloridine nephrotoxicity is due to the lack of development of the anionic transport system which is apparently necessary to achieve the high cortical concentrations of cephaloridine that result in renal injury.
在不同年龄段的兔子体内及体外研究了头孢菌素在兔肾皮质中的蓄积情况。通过将皮质切片在含头孢菌素的培养基中孵育测定的头孢菌素皮质浓度、皮质/血清比值以及切片/培养基比值，在出生后至约1月龄时从出生水平上升至成年水平。用普鲁卡因青霉素G预处理可刺激体内外蓄积头孢菌素的能力。数据表明，未成熟兔对头孢菌素肾毒性不敏感是由于阴离子转运系统发育不全，而该系统对于实现导致肾损伤的高皮质浓度头孢菌素显然是必需的。
