Noji S, Matsuo T, Koyama E, Yamaai T, Nohno T, Matsuo N, Taniguchi S
Okayama University Dental School, Japan.
Biochem Biophys Res Commun. 1990 Apr 16;168(1):343-9. doi: 10.1016/0006-291x(90)91714-4.
Although the retinal angiogenic and mitogenic factors have been identified to be acidic and basic fibroblast growth factors (aFGF and bFGF), little information has so far been available about the cells producing them and their function in retinal tissues. We found, by in situ hybridization, that the expression pattern of the aFGF gene differed remarkably from that of the bFGF gene in adult rat eyes. Our results demonstrated that the aFGF gene was produced by photoreceptor visual cells, neuronal cells in the inner nuclear layer and ganglion cells of the retina, in addition to pigment epithelial cells of the choroid, iris and ciliary body, and epithelial cells of the cornea, conjunctiva and lens, while bFGF was synthesized solely by the photoreceptor visual cells.
尽管视网膜血管生成因子和促有丝分裂因子已被确定为酸性和碱性成纤维细胞生长因子（aFGF和bFGF），但迄今为止，关于产生这些因子的细胞及其在视网膜组织中的功能的信息却很少。我们通过原位杂交发现，成年大鼠眼中aFGF基因的表达模式与bFGF基因的表达模式显著不同。我们的结果表明，除脉络膜、虹膜和睫状体的色素上皮细胞以及角膜、结膜和晶状体的上皮细胞外，aFGF基因由视网膜的光感受器视觉细胞、内核层的神经元细胞和神经节细胞产生，而bFGF仅由光感受器视觉细胞合成。
