Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, India.
Int J Biol Macromol. 2013 Apr;55:109-12. doi: 10.1016/j.ijbiomac.2012.12.038. Epub 2012 Dec 29.
The study involves mucoadhesive evaluation by formulating buccal discs using fluconazole as the model drug. The effect of compression pressure and gum cordia/lactose ratio on the ex vivo bioadhesion time and in vitro release of fluconazole was optimized using central composite experimental design. It was observed that the response ex vivo bioadhesion time was affected significantly by the proportion of gum cordia in the buccal discs while the in vitro release of fluconazole from the buccal discs was influenced significantly by the compression pressure. The optimized batch of buccal discs comprised of gum cordia/lactose - 0.66, fluconazole - 20 mg and was compressed at the pressure of 6600 kg. Further, it provided the ex vivo bioadhesion of 22 h and in vitro release of 80% in 24h. In conclusion, gum cordia is a promising bucoadhesive polymer.
该研究通过将氟康唑制成颊片来评估粘膜粘附性。使用中心复合实验设计优化了压缩压力和胶 Cordia/乳糖比，以优化氟康唑的体外释放和体外生物粘附时间。观察到体外生物粘附时间的响应受到颊片中胶 Cordia 比例的显著影响，而氟康唑从颊片中的体外释放受到压缩压力的显著影响。优化的颊片批次由胶 Cordia/乳糖-0.66、氟康唑-20mg 组成，并在 6600kg 的压力下压缩。此外，它在 24 小时内提供了 22 小时的体外生物粘附和 80%的体外释放。总之，胶 Cordia 是一种有前途的口腔粘附聚合物。
