（新西兰黑鼠×新西兰白鼠）F1代小鼠中Ly-1 B细胞与疾病活动。全身淋巴照射的影响。

Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation.

作者信息

Fariñas M C, Stall A M, Solovera J J, Tarlinton D M, Herzenberg L A, Strober S

机构信息

Department of Medicine, Stanford University School of Medicine, California 94305.

出版信息

Arthritis Rheum. 1990 Apr;33(4):553-62. doi: 10.1002/art.1780330413.

DOI:10.1002/art.1780330413

PMID:2328033

Abstract

The treatment of female (New Zealand black x New Zealand white)F1 mice with total lymphoid irradiation resulted in a prolonged remission of autoimmune disease activity. Total lymphoid irradiation-treated mice also showed a marked reduction of Ly-1 B cells, which lasted up to 3 months. The subsequent return of Ly-1 B cells to preirradiation levels was not associated with a simultaneous return of disease when measured by parameters such as IgG anti-DNA antibodies and spontaneous secretion of IgG by splenic cells. In cell sorting experiments, most of the cells spontaneously secreting IgG were found within the Ly-1- (CD5-) splenic B cell population.

摘要

用全身淋巴照射法治疗雌性（新西兰黑鼠×新西兰白鼠）F1小鼠，可使自身免疫疾病活动得到长期缓解。经全身淋巴照射治疗的小鼠还表现出Ly-1 B细胞显著减少，这种减少持续长达3个月。当通过诸如IgG抗DNA抗体和脾细胞自发分泌IgG等参数来衡量时，Ly-1 B细胞随后恢复到照射前水平与疾病的同时复发并无关联。在细胞分选实验中，发现大多数自发分泌IgG的细胞存在于Ly-1-（CD5-）脾B细胞群体中。