Arnold Lesley M, Fan Jinbo, Russell I Jon, Yunus Muhammad B, Khan Muhammad Asim, Kushner Irving, Olson Jane M, Iyengar Sudha K
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio 44106, USA.
Arthritis Rheum. 2013 Apr;65(4):1122-8. doi: 10.1002/art.37842.
Familial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia.
We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach.
The estimated sibling recurrence risk ratio (λs ) for fibromyalgia was 13.6 (95% confidence interval 10.0-18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was observed at markers D17S2196 (empirical P [Pe ]=0.00030) and D17S1294 (Pe=0.00035) on chromosome 17p11.2-q11.2.
The estimated sibling recurrence risk ratio (λs ) observed in this study suggests a strong genetic component of fibromyalgia. This is the first report of genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2-q11.2 region. Further investigation of these multicase families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia.
纤维肌痛的家族聚集现象已得到越来越多的认识。本研究的目的是进行全基因组连锁扫描，以确定纤维肌痛的易感基因座。
我们对纤维肌痛家族研究中116个家庭的成员进行了基因分型，并使用Haseman-Elston回归方法，对341个微卫星标记进行了纤维肌痛的无模型全基因组连锁分析。
根据报道的2%的人群患病率，纤维肌痛的估计同胞复发风险率（λs）为13.6（95%置信区间10.0-18.5）。在17号染色体p11.2-q11.2区域的标记D17S2196（经验P值[Pe]=0.00030）和D17S1294（Pe=0.00035）处观察到全基因组连锁的提示性证据。
本研究中观察到的估计同胞复发风险率（λs）表明纤维肌痛有很强的遗传成分。这是纤维肌痛与17号染色体p11.2-q11.2区域全基因组连锁提示性的首次报道。有必要对纤维肌痛家族研究中的这些多病例家庭进行进一步调查，以确定纤维肌痛潜在的因果风险变异。
