Ablin Jacob N
Department of Medicine H, Tel Aviv Sourasky Medical Center & Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Pain Rep. 2025 Apr 18;10(3):e1256. doi: 10.1097/PR9.0000000000001256. eCollection 2025 Jun.
Fibromyalgia, characterized by chronic widespread pain and fatigue, involves complex interactions between genetic predispositions and environmental triggers. This review delves into the multifaceted nature of fibromyalgia, emphasizing recent advances in understanding its pathogenesis through genetic, epigenetic, and environmental lenses. We explore the roles of specific genetic polymorphisms, such as those in the catechol-O-methyltransferase and serotonin transporter genes, and their correlation with the syndrome's susceptibility. The review also examines the significant impact of environmental factors, including physical trauma and stress, which potentiate the syndrome's severity. In addition, emerging research on the microbiome and epigenetic modifications provides new insights into the disease mechanisms, potentially guiding future therapeutic strategies. This article aims to synthesize current research findings and propose directions for future research, underscoring the necessity of a multidisciplinary approach to decipher the complexities of fibromyalgia.
纤维肌痛以慢性广泛性疼痛和疲劳为特征，涉及遗传易感性和环境触发因素之间的复杂相互作用。本综述深入探讨了纤维肌痛的多面性，强调了通过遗传、表观遗传和环境视角在理解其发病机制方面的最新进展。我们探讨了特定基因多态性的作用，如儿茶酚-O-甲基转移酶和血清素转运体基因中的多态性，以及它们与该综合征易感性的相关性。该综述还研究了环境因素的重大影响，包括身体创伤和压力，这些因素会加剧该综合征的严重程度。此外，关于微生物群和表观遗传修饰的新兴研究为疾病机制提供了新的见解，可能为未来的治疗策略提供指导。本文旨在综合当前的研究结果并为未来研究提出方向，强调采用多学科方法来解读纤维肌痛复杂性的必要性。
