Department of Radiology, University of Missouri, Columbia, MO, USA.
J Surg Oncol. 2013 May;107(6):597-601. doi: 10.1002/jso.23298. Epub 2012 Dec 27.
There is currently debate about the optimal timing and frequency of mammography follow-up after breast-conserving therapy (BCT). The purpose of this study was to determine if 6-month intervals for the first 2 years following BCT offer benefit over annual screening.
Three hundred ninety-nine patients who had lumpectomies between 1997 and 2009 and who were followed for at least 2 years with mammography were selected. The mammography yields for the first 2 years following BCT were compared to those of the general screening population. Also, patients were grouped as either compliant or noncompliant with the recommended 6-month intervals; Fischer's exact test was used to determine if there was a relationship between the grouping (compliant or noncompliant) and tumor recurrence.
Mammography yield was 0.94 and 2.87 per 1,000 for the first and second years, respectively, following surgery. Three hundred twenty-eight patients were categorized as compliant and 1 local recurrence was discovered in this group; 67 patients were labeled as noncompliant and 0 local recurrences were found in this group.
Mammography yield of cancer in the study population was not greater than the general population. There was no difference between the compliant and noncompliant groups regarding tumor recurrence.
目前对于保乳治疗（BCT）后行乳腺 X 线检查随访的最佳时间和频率存在争议。本研究旨在确定 BCT 后前 2 年每 6 个月进行一次检查是否优于每年筛查。
选择 1997 年至 2009 年间行乳房切除术且至少随访 2 年并行乳腺 X 线检查的 399 例患者。比较 BCT 后前 2 年的乳腺 X 线检查检出率与一般筛查人群的检出率。此外，将患者分为符合或不符合推荐的 6 个月随访间隔；采用 Fisher 确切检验确定分组（符合或不符合）与肿瘤复发之间是否存在关系。
术后第 1 年和第 2 年的乳腺 X 线检查检出率分别为 0.94 和 2.87/1000。328 例患者被归类为符合组，该组发现 1 例局部复发；67 例患者被归类为不符合组，该组未发现局部复发。
研究人群中癌症的乳腺 X 线检查检出率并不高于一般人群。符合组和不符合组在肿瘤复发方面无差异。
