Department of Neurology, Hope Center for Neurological Disorders, Washington University in St Louis, School of Medicine, St Louis, MO 63110, USA.
Ann Neurol. 2012 Dec;72(6):832-6. doi: 10.1002/ana.23684.
A new protocol suggests that patients with amyotrophic lateral sclerosis (ALS) are a viable source of tissue for organ transplantation. However, multiple lines of evidence suggest that many neurodegenerative diseases, including ALS, might progress due to transcellular propagation of protein aggregation among neurons. Transmission of the disease state from donor to host thus may be possible under the permissive circumstances of graft transplantation. We argue for careful patient selection and close longitudinal follow-up of recipients when harvesting organs from individuals with neurodegenerative disease, especially dominantly inherited forms.
一项新的方案表明，肌萎缩侧索硬化症（ALS）患者是器官移植的可行组织来源。然而，有多项证据表明，许多神经退行性疾病，包括 ALS，可能会由于神经元之间的蛋白聚集的细胞间传播而进展。因此，在移植的许可条件下，疾病状态可能从供体传播到宿主。当从具有神经退行性疾病的个体中获取器官时，我们主张对患者进行仔细的选择，并对受者进行密切的纵向随访，尤其是对于显性遗传形式。
