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肌萎缩侧索硬化症患者生前优先要求将肾脏捐献给亲属

Amyotrophic Lateral Sclerosis with a Priority Request for a Postmortem Kidney Donation to a Relative.

机构信息

Department of Neurology, Shodo-kai Southern Tohoku General Hospital, Japan.

Department of Neurology, Tohoku University Hospital, Japan.

出版信息

Intern Med. 2024 Jan 15;63(2):305-307. doi: 10.2169/internalmedicine.1574-23. Epub 2023 May 24.

DOI:10.2169/internalmedicine.1574-23
PMID:37225489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10864066/
Abstract

The patient was 57 years old when he was diagnosed with amyotrophic lateral sclerosis (ALS) at 1 year after developing bulbar symptoms. At 58 years old, he stated that he was considering donating his kidney to his son suffering from diabetic nephropathy. We confirmed the patient's intentions through repeated interviews before his death at 61 years old. Nephrectomy was performed 30 min after his cardiac death. Organ donation spontaneously proposed by an ALS patient should be considered in order to meet the requests of patients who want their families and other patients to live longer, thereby imparting a beneficial legacy through their deaths.

摘要

患者 57 岁时出现延髓症状 1 年后被诊断为肌萎缩侧索硬化症(ALS)。58 岁时,他表示考虑将自己的肾脏捐献给患有糖尿病肾病的儿子。在患者 61 岁去世前,我们通过多次访谈确认了他的意愿。在患者心脏死亡后 30 分钟进行了肾切除术。应考虑接受 ALS 患者主动提出的器官捐献,以满足希望自己的家人和其他患者活得更长的患者的要求,从而通过死亡留下有益的遗产。

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Intern Med. 2024 Jan 15;63(2):305-307. doi: 10.2169/internalmedicine.1574-23. Epub 2023 May 24.
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本文引用的文献

1
Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy.肌萎缩侧索硬化症的遗传学:在基因治疗时代寻找治疗靶点。
J Hum Genet. 2023 Mar;68(3):131-152. doi: 10.1038/s10038-022-01055-8. Epub 2022 Jun 13.
2
[Basics of Clinical Ethics].[临床伦理学基础]
Brain Nerve. 2020 Jul;72(7):677-687. doi: 10.11477/mf.1416201585.
3
Barriers to live and deceased kidney donation by patients with chronic neurological diseases: Implications for donor selection, donation timing, logistics, and regulatory compliance.慢性神经系统疾病患者活体和已故肾脏捐献的障碍:对供者选择、捐献时机、后勤和法规遵从性的影响。
Am J Transplant. 2019 Aug;19(8):2168-2173. doi: 10.1111/ajt.15230. Epub 2019 Feb 6.
4
Organ donation after euthanasia, morally acceptable under strict procedural safeguards.安乐死之后的器官捐赠,在严格的程序保障下是符合道德规范的。
Clin Transplant. 2018 Aug;32(8):e13294. doi: 10.1111/ctr.13294. Epub 2018 Jun 19.
5
Physician perceptions about living organ donation in patients with Amyotrophic Lateral Sclerosis.医生对肌萎缩侧索硬化症患者活体器官捐赠的看法。
Clin Neurol Neurosurg. 2017 Sep;160:125-129. doi: 10.1016/j.clineuro.2017.07.004. Epub 2017 Jul 5.
6
Organ donation following euthanasia starting at home.在家中实施安乐死后进行器官捐赠。
Transpl Int. 2017 Oct;30(10):1075-1076. doi: 10.1111/tri.13003. Epub 2017 Jul 27.
7
Organ donation after cardiac death in amyotrophic lateral sclerosis.心脏死亡后肌萎缩侧索硬化症的器官捐献。
Ann Neurol. 2012 Feb;71(2):154-6. doi: 10.1002/ana.22525. Epub 2012 Feb 14.
8
Organ donation after cardiac death from withdrawal of life support in patients with amyotrophic lateral sclerosis.心脏死亡后的器官捐赠:停止生命支持治疗的肌萎缩侧索硬化症患者。
J Palliat Med. 2012 Jan;15(1):16-9. doi: 10.1089/jpm.2011.0239. Epub 2011 Dec 7.
9
Amyotrophic lateral sclerosis.肌萎缩性侧索硬化症。
Lancet. 2011 Mar 12;377(9769):942-55. doi: 10.1016/S0140-6736(10)61156-7. Epub 2011 Feb 4.
10
Kidney transplantation between seven pairs of identical twins.七对同卵双胞胎之间的肾脏移植。
Ann Surg. 1958 Sep;148(3):343-59. doi: 10.1097/00000658-195809000-00004.