Wilks D, Walker L C, Habeshaw J A, Youle M, Gazzard B, Dalgleish A G
Division of Immunology, Clinical Research Centre, Harrow, UK.
AIDS. 1990 Feb;4(2):113-8. doi: 10.1097/00002030-199002000-00003.
The cell-surface antigen CD4 is the major receptor for HIV. Anti-CD4 autoantibodies and anti-idiotypic antibodies to murine monoclonal anti-CD4 antibodies have been described in HIV-infected people. Ninety-seven sera from HIV-infected people at all stages of disease were examined for the presence of anti-idiotypic antibodies to three anti-CD4 monoclonal antibodies. None were found. The same sera were screened for antibodies reactive with soluble CD4, and five (5.2%) were positive. These antibodies did not recognize native CD4, and it is thought unlikely that they arise as anti-idiotypes to anti-gp120 antibodies.
细胞表面抗原CD4是HIV的主要受体。在HIV感染者中已发现抗CD4自身抗体以及针对鼠抗CD4单克隆抗体的抗独特型抗体。对97份处于疾病各阶段的HIV感染者血清进行检测，以查找针对三种抗CD4单克隆抗体的抗独特型抗体。未发现此类抗体。对相同的血清进行筛查，以查找与可溶性CD4反应的抗体，有5份（5.2%）呈阳性。这些抗体不能识别天然CD4，并且认为它们不太可能作为抗gp120抗体的抗独特型抗体产生。
