Lundin K, Holmberg V, Sandström E, Wigzell H
Department of Immunology, Karolinska Institute, Stockholm, Sweden.
J Acquir Immune Defic Syndr (1988). 1992;5(7):658-65.
An earlier study showed that approximately 5% of HIV-seropositive human sera contain gp120 antibodies that mimic CD4, seen as anti-idiotypic to the CD4 monoclonal T4.2. The present study shows the existence of a second type of CD4-mimicking gp120 antibody, which specifically binds to the CD4 monoclonal, OKT4A. This anti-idiotypic antibody to OKT4A is less frequent than the antibody reacting with T4.2. In two patients studied, this OKT4A binding antibody seems to appear as early during infection as the anti-idiotypic antibody to T4.2; however, the concentration varies more with time. In order to evaluate the possible clinical relevance of these CD4-mimicking antibodies, sera from 208 HIV-seropositive and 204 healthy seronegative individuals were screened. There was a significantly higher frequency of anti-idiotypic antibodies to T4.2 among HIV-positive individuals compared to healthy controls (p = 0.05). However, no correlation was found between the presence of CD4-mimicking antibodies and clinical classification of HIV-infected individuals.
一项较早的研究表明，约5%的HIV血清反应阳性的人血清中含有模仿CD4的gp120抗体，被视为CD4单克隆抗体T4.2的抗独特型抗体。本研究显示存在第二种模仿CD4的gp120抗体，它能特异性结合CD4单克隆抗体OKT4A。这种针对OKT4A的抗独特型抗体比与T4.2反应的抗体出现频率更低。在研究的两名患者中，这种与OKT4A结合的抗体似乎在感染早期与针对T4.2的抗独特型抗体同时出现；然而，其浓度随时间变化更大。为了评估这些模仿CD4的抗体可能的临床相关性，对208名HIV血清反应阳性个体和204名健康血清反应阴性个体的血清进行了筛查。与健康对照相比，HIV阳性个体中针对T4.2的抗独特型抗体频率显著更高（p = 0.05）。然而，未发现模仿CD4的抗体的存在与HIV感染个体的临床分类之间存在相关性。
