Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia.
Phytother Res. 2013 Sep;27(9):1407-13. doi: 10.1002/ptr.4864. Epub 2012 Dec 19.
Standardized extracts of the traditional Ayurvedic medicine Bacopa monnieri (BM) (Brahmi) have been recently shown to have cognitive enhancing effects in chronic administration studies. Pre-clinical work has also identified a number of acute anxiolytic, nootropic, and cardiovascular effects of BM. There has, however, been little research on the acute effects of BM on cognitive function. The current study aimed to assess the acute effects of a specific extract of BM (KeenMind®-CDRI 08) in a double-blind, placebo-controlled study in normal healthy participants who completed a cognitively demanding series of tests. Twenty-four healthy volunteers completed six repetitions of the Cognitive Demand Battery (CDB) after consuming a placebo, 320 mg BM or 640 mg of BM in a cross-over design and provided cardiovascular and mood assessments before and after treatment. Change from baseline scores indicated that the 320 mg dose of BM improved performance at the first, second, and fourth repetition post-dosing on the CDB, and the treatments had no effect upon cardiovascular activity or in attenuating task-induced ratings of stress and fatigue. It was concluded that assessment of an earlier pharmacological window and use of less memory-specific cognitive tests together with more temporally sensitive measures of brain activity may improve our understanding of the acute neurocognitive properties of BM.
最近的研究表明，传统的印度草药 Bacopa monnieri（BM）（ Brahmi ）的标准化提取物在慢性给药研究中具有增强认知的作用。临床前工作还确定了 BM 的许多急性抗焦虑、益智和心血管作用。然而，关于 BM 对认知功能的急性影响的研究甚少。本研究旨在评估一种特定的 BM 提取物（KeenMind®-CDRI 08）在正常健康参与者中的急性影响，这些参与者在一项双盲、安慰剂对照的研究中完成了一系列认知要求很高的测试。二十四名健康志愿者在交叉设计中分别服用安慰剂、320mg BM 或 640mg BM 后，完成了认知需求电池（CDB）的六次重复，并在治疗前后进行了心血管和情绪评估。与基线分数的变化表明，320mg BM 剂量可改善给药后 CDB 的第一次、第二次和第四次重复的表现，而这些治疗方法对心血管活动或减轻任务引起的压力和疲劳感没有影响。研究结论认为，评估更早的药理学窗口并使用较少记忆特异性的认知测试以及更具时间敏感性的大脑活动测量可能会提高我们对 BM 的急性神经认知特性的理解。
