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草药和天然生物活性产品作为潜在疗法:关于促认知和脑增强剂观点的综述

Herbal drugs and natural bioactive products as potential therapeutics: A review on pro-cognitives and brain boosters perspectives.

作者信息

Halder Swati, Anand Uttpal, Nandy Samapika, Oleksak Patrik, Qusti Safaa, Alshammari Eida M, El-Saber Batiha Gaber, Koshy Eapen P, Dey Abhijit

机构信息

Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, West Bengal, India.

Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj 211007, Uttar Pradesh, India.

出版信息

Saudi Pharm J. 2021 Aug;29(8):879-907. doi: 10.1016/j.jsps.2021.07.003. Epub 2021 Jul 15.

Abstract

Memory, one of the most vital aspects of the human brain, is necessary for the effective survival of an individual. 'Memory' can be defined in various ways but in an overall view, memory is the retention of the information that the brain grasps. Different factors are responsible for the disbalance in the brain's hippocampus region and the acetylcholine level, which masters the memory and cognitive functions. Plants are a source of pharmacologically potent drug molecules of high efficacy. Recently herbal medicine has evolved rapidly, gaining great acceptance worldwide due to their natural origin and fewer side effects. In this review, the authors have discussed the mechanisms and pharmacological action of herbal bioactive compounds to boost memory. Moreover, this review presents an update of different herbs and natural products that could act as memory enhancers and how they can be potentially utilized in the near future for the treatment of severe brain disorders. In addition, the authors also discuss the differences in biological activity of the same herb and emphasize the requirement for a higher standardization in cultivation methods and plant processing. The demand for further studies evaluating the interactions of herbal drugs is mentioned.

摘要

记忆是人类大脑最为重要的方面之一,是个体有效生存所必需的。“记忆”可以通过多种方式来定义,但总体而言,记忆是大脑所掌握信息的留存。大脑海马体区域和乙酰胆碱水平的失衡由不同因素导致,而乙酰胆碱掌控着记忆和认知功能。植物是具有高效药理活性药物分子的来源。近来,草药医学发展迅速,因其天然来源和较少的副作用而在全球范围内获得了广泛认可。在这篇综述中,作者们讨论了草药生物活性化合物增强记忆的机制和药理作用。此外,本综述介绍了不同草药和天然产物作为记忆增强剂的最新情况,以及它们在不久的将来如何可能用于治疗严重脑部疾病。此外,作者们还讨论了同一草药生物活性的差异,并强调了种植方法和植物加工中更高标准化的要求。文中提到了进一步研究评估草药药物相互作用的需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aab3/8363108/30d5f880a81a/gr1.jpg

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