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输注速率的预测：计算机研究

Prediction of infusion rates: computer study.

作者信息

Harrison M J

机构信息

Auckland Hospital, New Zealand.

出版信息

Br J Anaesth. 1990 Mar;64(3):283-6. doi: 10.1093/bja/64.3.283.

DOI:10.1093/bja/64.3.283
PMID:2328176
Abstract

The administration of two test doses in the ratio 1:0.5 has been shown to provide sufficient data (time intervals) to predict the infusion rate necessary to maintain the concentration of a drug at the therapeutic threshold in a two-compartment pharmacokinetic model. If the relationship between the durations of action of the test doses is linear, only one test dose may be needed to predict the infusion rate.

摘要

已证明以1:0.5的比例给予两个试验剂量能够提供足够的数据（时间间隔），以预测在二室药代动力学模型中维持药物浓度在治疗阈值所需的输注速率。如果试验剂量的作用持续时间之间的关系呈线性，则可能仅需一个试验剂量来预测输注速率。

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Prediction of infusion rates: computer study.输注速率的预测：计算机研究
Br J Anaesth. 1990 Mar;64(3):283-6. doi: 10.1093/bja/64.3.283.
2
Consecutive intravenous infusions: simulation of two compartment pharmacokinetic drugs.连续静脉输注：二室药代动力学药物的模拟
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Anesthesiology. 1994 Aug;81(2):316-24; discussion 25A.
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Constant-rate intravenous infusion methods for estimating steady-state volumes of distribution and mean residence times in the body for drugs undergoing reversible metabolism.用于估算经历可逆代谢的药物在体内的稳态分布容积和平均驻留时间的恒速静脉输注方法。
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