连续静脉输注：二室药代动力学药物的模拟
Consecutive intravenous infusions: simulation of two compartment pharmacokinetic drugs.
作者信息
Hieb B R, Shrewsbury B
出版信息
Comput Programs Biomed. 1980 Dec;12(2-3):96-104. doi: 10.1016/0010-468x(80)90055-0.
A program is presented to simulate the blood concentrations which result from multiple, consecutive, constant rate intravenous infusions of drugs displaying two compartment kinetics. The program utilizes the principle of superposition and was developed for a Hewlett-Packard model 97 programmable calculator. The program can handle form 1-8 consecutive infusions, each with its own infusion rate and duration. Post-infusion blood concentrations can also be readily obtained A modification of the main program is also presented which enables the stimulation of blood concentration--time data pairs without operator assistance. A desired increment of time specified, and the program will provide concentration--time data pairs between specified starting and ending times.
本文介绍了一个程序，用于模拟多次连续恒速静脉输注呈现二室动力学的药物所产生的血药浓度。该程序利用叠加原理，是为惠普97型可编程计算器开发的。该程序可以处理1至8次连续输注，每次输注都有自己的输注速率和持续时间。输注后血药浓度也能轻松获得。还介绍了主程序的一种修改版本，它能够在无需操作人员协助的情况下模拟血药浓度-时间数据对。指定所需的时间增量，程序将提供指定起始时间和结束时间之间的浓度-时间数据对。
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