体内和体外霍乱毒素处理对T细胞和巨噬细胞的调节作用。

Modulation of T cells and macrophages by cholera toxin treatment in vivo and in vitro.

作者信息

Friedman H, Lyons S

出版信息

Adv Exp Med Biol. 1979;121(A):343-50. doi: 10.1007/978-1-4684-3593-1_30.

Abstract

Cholera Toxin influences the antibody response to SRBC. Enhanced responses occur in vivo and in vitro when CT is added together with antigen. However, CT depresses antibody formation when given in vivo before antigen but enhances in vitro responses under the same conditions. Modulation of antibody formation appeared due to effects of T lymphocytes as well as macrophages. Co-cultivation of immunologically impaired spleen cells from CT pretreated animals with macrophage-rich peritoneal cells or educated T cells increased the antibody response.

摘要

霍乱毒素会影响对绵羊红细胞的抗体反应。当霍乱毒素与抗原一起添加时，体内和体外的反应都会增强。然而，在抗原之前体内给予霍乱毒素会抑制抗体形成，但在相同条件下体外反应会增强。抗体形成的调节似乎是由于T淋巴细胞以及巨噬细胞的作用。将经霍乱毒素预处理动物的免疫受损脾细胞与富含巨噬细胞的腹膜细胞或受过训练的T细胞共同培养，会增加抗体反应。