Drath D B, Davies P, Karnovsky M L, Huber G L
Adv Exp Med Biol. 1979;121(A):555-68. doi: 10.1007/978-1-4684-3593-1_46.
Our results indicate that tobacco smoke exposure to varying duration causes morphological, biochemical and functional alterations in pulmonary alveolar macrophages. The results of these changes is a population of alveolar macrophages made up of larger cells, with a reduced nucleus-cytoplasmic ratio, which are heavily loaded with heterolysosomes containing lipid. Though their fractional complement of mitochondria remains the same, an increase in the inner mitochondrial membrane surface area may be related to an enhanced oxidative metabolism. The cell is biochemically activated particularly following chronic exposure and is functionally impaired with respect to phagocytosis.
我们的结果表明，暴露于不同时长的烟草烟雾会导致肺泡巨噬细胞出现形态、生化和功能改变。这些变化的结果是形成了一群由较大细胞组成的肺泡巨噬细胞，其核质比降低，大量充满含脂质的异溶酶体。尽管它们线粒体的比例保持不变，但线粒体内膜表面积的增加可能与氧化代谢增强有关。特别是在长期暴露后，细胞在生化方面被激活，并且在吞噬功能上受损。
