Drath D B, Karnovsky M L, Huber G L
Inflammation. 1979 Jul;3(3):281-8. doi: 10.1007/BF00914185.
Tobacco smoke affected both the metabolism and function of pulmonary alveolar macrophages (PAM). Phagocytosis of viable Staphylococcus aureus and inert starch particles was minimally but consistently depressed in PAM from rats exposed to tobacco smoke for six months. Oxygen consumption, superoxide and hydrogen peroxide release, and hexose monophosphate shunt activity were elevated in cells from smokers. Oxidation of glucose, labelled in the carbon-six position, remained unchanged. All observed effects of tobacco smoke on oxygen metabolism occurred during phagocytosis and did not affect the basal metabolism of the nonstimulated cell.
烟草烟雾会影响肺泡巨噬细胞（PAM）的代谢和功能。在暴露于烟草烟雾六个月的大鼠的PAM中，对活金黄色葡萄球菌和惰性淀粉颗粒的吞噬作用虽轻微但持续受到抑制。吸烟者细胞中的氧气消耗、超氧化物和过氧化氢释放以及磷酸己糖旁路活性均有所升高。在碳-6位置标记的葡萄糖氧化保持不变。烟草烟雾对氧代谢的所有观察到的影响都发生在吞噬过程中，且不影响未受刺激细胞的基础代谢。
