金黄色葡萄球菌与慢性气道疾病。
Staphylococcus aureus and Chronic Airway Disease.
机构信息
From the Upper Airway Research Laboratory (URL), Department of Oto-Rhino-Laryngology, Ghent University Hospital, Ghent University, Belgium; and *Centre Hospitalier Universitaire de Québec, Pavillon Saint-François d'Assise, Québec, Canada.
出版信息
World Allergy Organ J. 2010 Aug;3(8):223-8. doi: 10.1097/WOX.0b013e3181ecd8ae.
Abstract
Staphylococcus aureus (S. aureus) is correlated with the development of persistent severe inflammatory disease of the upper airway including chronic rhinosinusitis with nasal polyps. This inflammation of the upper airways is characterized by a T-helper 2-driven disease: interleukin-5 is significantly increased and local production of immunoglobulin E is observed. S. aureus and its enterotoxins are deregulating the tissue inflammation at different levels: structural cells and the innate and adaptive immune system. Knowing the triggers of the pathomechanisms involved will greatly help us to find new therapeutic approaches to resolve this chronic inflammatory process.
摘要
金黄色葡萄球菌（S. aureus）与上呼吸道持续性严重炎症性疾病的发展相关，包括伴有鼻息肉的慢性鼻-鼻窦炎。这种上呼吸道炎症的特征是 Th2 驱动的疾病：白细胞介素-5 显著增加，并且观察到局部免疫球蛋白 E 的产生。金黄色葡萄球菌及其肠毒素在不同层面上扰乱组织炎症：结构细胞以及先天和适应性免疫系统。了解参与的发病机制的触发因素将极大地帮助我们找到新的治疗方法来解决这种慢性炎症过程。
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