Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.
Am J Surg Pathol. 2013 Feb;37(2):282-6. doi: 10.1097/PAS.0b013e318267aee6.
A total of 704 cases of thyroid cancer were retrospectively reviewed (2005 to 2011) to assess the contribution of frozen section (FS) to preoperative fine-needle aspiration (FNA). There were 613 papillary carcinomas (87.1%), of which 237 were <1.0 cm. FNA was diagnostic or suspicious in 39.9% of micropapillary thyroid carcinomas and 75.8% of papillary carcinomas. FS was diagnostic in 52.3% and 76.6%, respectively. In no instance did the FS diagnosis change the procedure (total or near-total thyroidectomy). Neither FNA nor FS was diagnostically definitive in follicular neoplasms. A diagnosis of follicular carcinoma was made only after thorough histologic analysis. FS should have a less prominent role in the management of thyroid masses, especially in the context of total thyroidectomy for benign disease. FS may be more productively applied to the identification of metastatic lymph nodes or parathyroids in the surgical field.
共回顾性分析了 704 例甲状腺癌病例（2005 年至 2011 年），以评估冰冻切片（FS）对术前细针穿刺抽吸（FNA）的贡献。其中 613 例为乳头状癌（87.1%），其中 237 例<1.0cm。微乳头状甲状腺癌和乳头状癌的 FNA 诊断率分别为 39.9%和 75.8%。FS 的诊断率分别为 52.3%和 76.6%。FS 诊断均未改变手术方式（全甲状腺切除术或近全甲状腺切除术）。FNA 和 FS 在滤泡性肿瘤的诊断中均无明确作用。只有在进行彻底的组织学分析后，才能诊断为滤泡状癌。FS 在甲状腺肿块的治疗中作用应较小，尤其是在良性疾病行全甲状腺切除术的情况下。FS 可能更有助于在手术区域中识别转移性淋巴结或甲状旁腺。
