From the 1Allergy Unit, Clinica San Carlo, Paderno Dugnano (Milan), Italy; 2Department of Internal Medicine, University of Milan and IRCCS Foundation Maggiore Hospital, Mangiagalli and Regina Elena, Milan, Italy; and 3Allergy and Clinical Immunology Unit, IRCCS Foundation Maggiore Hospital, Mangiagalli and Regina Elena, Milan, Italy.
World Allergy Organ J. 2009 Sep;2(9):213-7. doi: 10.1097/WOX.0b013e3181bb965f.
Although their number may be increased in skin lesions, eosinophils have been rather neglected as possible participants to the pathogenesis of chronic urticaria because of the absence of peripheral eosinophilia in patients with this disease. However, recent data suggest a potentially relevant role played by activated eosinophils both in triggering the tissue factor pathway of coagulation cascade and as a source of vascular endothelial growth factor. Such phenomena seem more pronounced in patients showing a more severe disease. The present study will rediscuss the potential role of this cell line in chronic urticaria in the light of these recent observations.
尽管在皮肤损伤中嗜酸性粒细胞的数量可能会增加，但由于患有这种疾病的患者外周血嗜酸性粒细胞无增多，因此它们作为慢性荨麻疹发病机制的可能参与者而被忽视。然而，最近的数据表明，活化的嗜酸性粒细胞在触发凝血级联的组织因子途径以及作为血管内皮生长因子的来源方面可能发挥着重要作用。在病情较重的患者中，这些现象似乎更为明显。本研究将根据这些新的观察结果重新讨论这条细胞通路在慢性荨麻疹中的潜在作用。
