Department of Pediatrics, University of California, San Francisco, California, USA.
Curr Opin Gastroenterol. 2013 Mar;29(2):170-6. doi: 10.1097/MOG.0b013e32835ca11d.
Nonalcoholic steatohepatitis (NASH) is increasing in prevalence, in tandem with the U.S. obesity epidemic, in both children and adults. Identifying specific dietary components that drive NASH is important for successful management of this disease.
Weight loss of 5-10% improves NASH. In addition, fructose and trans-fats, two components of the Western 'fast-food' diet, have unique metabolic effects that suggest they may be key contributors to NASH. However, further research is needed to clarify the utility of restricting these nutrients in treating NASH.
Overall reductions in body weight, through reduced calorie intake and increased physical activity, are the current mainstays of NASH treatment. Reducing fructose and trans-fat intake, independent of weight loss, may be critical to improving or preventing progression of NASH.
非酒精性脂肪性肝炎（NASH）在美国肥胖流行的同时，在儿童和成人中的发病率都在增加。确定导致 NASH 的特定饮食成分对于成功治疗这种疾病很重要。
体重减轻 5-10%可改善 NASH。此外，果糖和反式脂肪，西方“快餐”饮食的两个组成部分，具有独特的代谢作用，表明它们可能是 NASH 的关键因素。然而，需要进一步的研究来阐明限制这些营养物质在治疗 NASH 中的效用。
通过减少热量摄入和增加体力活动来整体减轻体重，是目前 NASH 治疗的主要方法。减少果糖和反式脂肪的摄入，独立于体重减轻，可能对改善或预防 NASH 的进展至关重要。
