• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

儿童骨髓炎和化脓性关节炎:当前概念。

Osteomyelitis and septic arthritis in children: current concepts.

机构信息

Hospital for Special Surgery, New York, New York 10021, USA.

出版信息

Curr Opin Pediatr. 2013 Feb;25(1):58-63. doi: 10.1097/MOP.0b013e32835c2b42.

DOI:10.1097/MOP.0b013e32835c2b42
PMID:23283291
Abstract

PURPOSE OF REVIEW

The cause, epidemiology, diagnosis, and treatment of osteoarticular infections have changed considerably in recent years. The current review includes the most up to date literature on pediatric septic arthritis and osteomyelitis.

RECENT FINDINGS

There is controversy over whether osteoarticular infection rates are increasing or decreasing. Changes in epidemiology may be related to improved methods of diagnosis. The pathogens responsible for osteoarticular infections in children have changed with alterations in immunization practices, emergence of resistant bacteria, and changes in patterns of immune modulating diseases and medications in children. Special culture techniques and PCR may help to identify pathogens that are difficult to culture. Surgical debridement is typically required for joint infections and chronic osteomyelitis, whereas acute osteomyelitis can typically be treated with medication alone. Needle aspiration/irrigation alone has been described as an alternative to surgical incision/drainage for septic arthritis, but this practice has not been widely adopted. Intravenous antibiotic therapy for 2-4 days followed by 20 days of oral therapy is effective for treating uncomplicated cases of osteomyelitis, whereas 2-4 days of intravenous antibiotics followed by 10 days of oral therapy is sufficient for septic arthritis. Steroids have shown some improved short-term clinical outcomes in patients with septic arthritis.

SUMMARY

Up to date knowledge of emerging pathogens, utilization of modern diagnostic techniques and implementation of new shorter treatment regimens can optimize the treatment of pediatric septic arthritis and osteomyelitis.

摘要

目的综述

近年来,骨关节炎感染的病因、流行病学、诊断和治疗发生了重大变化。本综述包括了最新的儿科脓毒性关节炎和骨髓炎文献。

最近的发现

关于骨关节炎感染率是增加还是减少存在争议。流行病学的变化可能与诊断方法的改进有关。导致儿童骨关节炎感染的病原体随着免疫接种实践的改变、耐药菌的出现以及儿童免疫调节疾病和药物模式的变化而发生了变化。特殊的培养技术和 PCR 可能有助于鉴定难以培养的病原体。关节感染和慢性骨髓炎通常需要手术清创,而急性骨髓炎通常可以单独用药物治疗。单纯的针吸/冲洗已被描述为治疗化脓性关节炎的替代方法,但这种方法尚未得到广泛采用。静脉内抗生素治疗 2-4 天,然后口服治疗 20 天,对治疗简单的骨髓炎有效,而静脉内抗生素治疗 2-4 天,然后口服治疗 10 天,对治疗化脓性关节炎有效。类固醇在治疗化脓性关节炎患者方面显示出一些短期临床结果的改善。

总结

了解新出现的病原体、利用现代诊断技术和实施新的更短的治疗方案可以优化儿科脓毒性关节炎和骨髓炎的治疗。

相似文献

1
Osteomyelitis and septic arthritis in children: current concepts.儿童骨髓炎和化脓性关节炎:当前概念。
Curr Opin Pediatr. 2013 Feb;25(1):58-63. doi: 10.1097/MOP.0b013e32835c2b42.
2
Acute hematogenous osteomyelitis and septic arthritis in children: clinical characteristics and outcomes study.儿童急性血源性骨髓炎和化脓性关节炎:临床特征与转归研究
J Med Assoc Thai. 2011 Aug;94 Suppl 3:S209-16.
3
Prospective survey of acute osteoarticular infections in a French paediatric orthopedic surgery unit.法国小儿矫形外科单位急性骨关节炎感染的前瞻性调查。
Clin Microbiol Infect. 2013 Sep;19(9):822-8. doi: 10.1111/clm.12031.
4
Update on the Management of Pediatric Acute Osteomyelitis and Septic Arthritis.小儿急性骨髓炎和化脓性关节炎的治疗进展
Int J Mol Sci. 2016 Jun 1;17(6):855. doi: 10.3390/ijms17060855.
5
Concurrent septic arthritis and osteomyelitis in children.儿童并发化脓性关节炎和骨髓炎
J Pediatr Orthop. 2013 Jun;33(4):464-7. doi: 10.1097/BPO.0b013e318278484f.
6
Simplifying the treatment of acute bacterial bone and joint infections in children.简化儿童急性细菌性骨和关节感染的治疗。
Expert Rev Anti Infect Ther. 2011 Dec;9(12):1125-31. doi: 10.1586/eri.11.140.
7
Osteomyelitis is Commonly Associated With Septic Arthritis of the Shoulder in Children.骨髓炎常与儿童肩关节化脓性关节炎相关。
J Pediatr Orthop. 2017 Dec;37(8):547-552. doi: 10.1097/BPO.0000000000000709.
8
Bone and joint infections.骨骼和关节感染。
Pediatr Clin North Am. 2013 Apr;60(2):425-36. doi: 10.1016/j.pcl.2012.12.006. Epub 2013 Jan 12.
9
Recent lessons for the management of bone and joint infections.最近有关骨与关节感染处理的经验教训。
J Infect. 2014 Jan;68 Suppl 1:S51-6. doi: 10.1016/j.jinf.2013.09.014. Epub 2013 Oct 9.
10
[Short duration of initial intravenous treatment in 70 pediatric patients with osteoarticular infections].70例小儿骨关节感染患者初始静脉治疗的短疗程
Rev Chilena Infectol. 2008 Feb;25(1):30-6. Epub 2008 Feb 8.

引用本文的文献

1
A severe course in paediatric acute haematogenous osteomyelitis: Predictor variables present on admission.儿童急性血源性骨髓炎的严重病程:入院时的预测变量
J Child Orthop. 2025 Jun 24:18632521251346650. doi: 10.1177/18632521251346650.
2
Predicting the presence of adjacent septic arthritis in children with acute hematogenous osteomyelitis.预测急性血源性骨髓炎患儿是否存在相邻化脓性关节炎。
BMC Musculoskelet Disord. 2025 May 27;26(1):523. doi: 10.1186/s12891-025-08671-3.
3
Reconstruction Using Hinged Knee Replacement of an Unusual Knee Deformity as a Sequelae of Paediatric Septic Arthritis: A Case Report.
铰链式膝关节置换术重建小儿化脓性关节炎后遗症所致罕见膝关节畸形:一例报告
Cureus. 2025 Apr 16;17(4):e82347. doi: 10.7759/cureus.82347. eCollection 2025 Apr.
4
Intravenous Dexamethasone Use and Outcomes in Children Hospitalized With Septic Arthritis.静脉注射地塞米松在脓毒性关节炎住院儿童中的应用及结局
Hosp Pediatr. 2025 May 1;15(5):369-377. doi: 10.1542/hpeds.2024-008047.
5
Multicenter Retrospective Analysis of 702 Pediatric Cases of Bone and Joint Infections: Definition of Clinical and Biological Features to Discriminate , , and Other Bacterial Infections.702例儿童骨与关节感染的多中心回顾性分析:鉴别金黄色葡萄球菌、凝固酶阴性葡萄球菌及其他细菌感染的临床和生物学特征定义
Pathogens. 2025 Feb 4;14(2):147. doi: 10.3390/pathogens14020147.
6
Plasma Microbial Cell-free DNA Sequencing for the Detection of Kingella kingae Pediatric Spinal Infections.用于检测金氏金杆菌小儿脊髓感染的血浆微生物无细胞DNA测序
Pediatr Infect Dis J. 2025 Jun 1;44(6):582-588. doi: 10.1097/INF.0000000000004743. Epub 2025 Feb 21.
7
Analysis of antimicrobial resistance and clinical features of Staphylococcus aureus-infected bone and joint infections in children.儿童金黄色葡萄球菌感染性骨与关节感染的耐药性及临床特征分析
BMC Pediatr. 2025 Jan 31;25(1):83. doi: 10.1186/s12887-025-05433-x.
8
Investigating Osteomyelitis as a Rare Adverse Effect of Vaccination in the Pediatric Population.调查骨髓炎作为儿科人群疫苗接种罕见不良反应的情况。
Pathogens. 2024 Nov 7;13(11):972. doi: 10.3390/pathogens13110972.
9
Microbiological Spectrum of Osteoarticular Infections and Their Management in Mongolian Children.蒙古儿童骨关节感染的微生物谱及其管理
Glob Pediatr Health. 2024 Nov 19;11:2333794X241298801. doi: 10.1177/2333794X241298801. eCollection 2024.
10
Predictors of Methicillin-resistant Staphylococcus aureus infection in children with acute osteomyelitis.儿童急性骨髓炎中耐甲氧西林金黄色葡萄球菌感染的预测因素。
Ital J Pediatr. 2024 Oct 10;50(1):212. doi: 10.1186/s13052-024-01780-0.