Hospital for Special Surgery, New York, New York 10021, USA.
Curr Opin Pediatr. 2013 Feb;25(1):58-63. doi: 10.1097/MOP.0b013e32835c2b42.
The cause, epidemiology, diagnosis, and treatment of osteoarticular infections have changed considerably in recent years. The current review includes the most up to date literature on pediatric septic arthritis and osteomyelitis.
There is controversy over whether osteoarticular infection rates are increasing or decreasing. Changes in epidemiology may be related to improved methods of diagnosis. The pathogens responsible for osteoarticular infections in children have changed with alterations in immunization practices, emergence of resistant bacteria, and changes in patterns of immune modulating diseases and medications in children. Special culture techniques and PCR may help to identify pathogens that are difficult to culture. Surgical debridement is typically required for joint infections and chronic osteomyelitis, whereas acute osteomyelitis can typically be treated with medication alone. Needle aspiration/irrigation alone has been described as an alternative to surgical incision/drainage for septic arthritis, but this practice has not been widely adopted. Intravenous antibiotic therapy for 2-4 days followed by 20 days of oral therapy is effective for treating uncomplicated cases of osteomyelitis, whereas 2-4 days of intravenous antibiotics followed by 10 days of oral therapy is sufficient for septic arthritis. Steroids have shown some improved short-term clinical outcomes in patients with septic arthritis.
Up to date knowledge of emerging pathogens, utilization of modern diagnostic techniques and implementation of new shorter treatment regimens can optimize the treatment of pediatric septic arthritis and osteomyelitis.
近年来,骨关节炎感染的病因、流行病学、诊断和治疗发生了重大变化。本综述包括了最新的儿科脓毒性关节炎和骨髓炎文献。
关于骨关节炎感染率是增加还是减少存在争议。流行病学的变化可能与诊断方法的改进有关。导致儿童骨关节炎感染的病原体随着免疫接种实践的改变、耐药菌的出现以及儿童免疫调节疾病和药物模式的变化而发生了变化。特殊的培养技术和 PCR 可能有助于鉴定难以培养的病原体。关节感染和慢性骨髓炎通常需要手术清创,而急性骨髓炎通常可以单独用药物治疗。单纯的针吸/冲洗已被描述为治疗化脓性关节炎的替代方法,但这种方法尚未得到广泛采用。静脉内抗生素治疗 2-4 天,然后口服治疗 20 天,对治疗简单的骨髓炎有效,而静脉内抗生素治疗 2-4 天,然后口服治疗 10 天,对治疗化脓性关节炎有效。类固醇在治疗化脓性关节炎患者方面显示出一些短期临床结果的改善。
了解新出现的病原体、利用现代诊断技术和实施新的更短的治疗方案可以优化儿科脓毒性关节炎和骨髓炎的治疗。