Does enteral protein administration stimulate duodenal mucosa protein synthesis through an mTORC1-independent signaling pathway?
作者信息
Kimball Scot R
出版信息
Am J Clin Nutr. 2013 Feb;97(2):235-6. doi: 10.3945/ajcn.112.054999. Epub 2013 Jan 2.
Abstract
摘要
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Does enteral protein administration stimulate duodenal mucosa protein synthesis through an mTORC1-independent signaling pathway?肠内蛋白质给药是否通过不依赖mTORC1的信号通路刺激十二指肠黏膜蛋白质合成？
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引用本文的文献
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Enteral delivery of proteins enhances the expression of proteins involved in the cytoskeleton and protein biosynthesis in human duodenal mucosa.蛋白质的肠内递送可增强人十二指肠黏膜中参与细胞骨架和蛋白质生物合成的蛋白质的表达。
Am J Clin Nutr. 2015 Aug;102(2):359-67. doi: 10.3945/ajcn.114.104216. Epub 2015 Jun 24.
本文引用的文献
1
Enteral delivery of proteins stimulates protein synthesis in human duodenal mucosa in the fed state through a mammalian target of rapamycin-independent pathway.肠内给予蛋白质可通过雷帕霉素靶蛋白（mTOR）非依赖性途径刺激进食状态下人十二指肠黏膜的蛋白质合成。
Am J Clin Nutr. 2013 Feb;97(2):286-94. doi: 10.3945/ajcn.112.046946. Epub 2013 Jan 2.
2
Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.真核起始因子 2 的磷酸化与代谢中的翻译调控
Adv Nutr. 2012 May 1;3(3):307-21. doi: 10.3945/an.112.002113.
3
Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids.哺乳动物雷帕霉素靶蛋白复合物 1 的激活对于必需氨基酸刺激人体骨骼肌蛋白质合成是必需的。
J Nutr. 2011 May;141(5):856-62. doi: 10.3945/jn.111.139485. Epub 2011 Mar 23.
4
Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis.在人体中施用雷帕霉素可阻断收缩诱导的骨骼肌蛋白质合成增加。
J Physiol. 2009 Apr 1;587(Pt 7):1535-46. doi: 10.1113/jphysiol.2008.163816. Epub 2009 Feb 2.
5
A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B.一种由氨基酸控制翻译起始的新机制，由真核起始因子2B的磷酸化介导。
Mol Cell Biol. 2008 Mar;28(5):1429-42. doi: 10.1128/MCB.01512-07. Epub 2007 Dec 26.
6
Amino acids as regulators of gene expression.
Nutr Metab (Lond). 2004 Aug 17;1(1):3. doi: 10.1186/1743-7075-1-3.
7
Developmental changes in the feeding-induced stimulation of translation initiation in muscle of neonatal pigs.新生仔猪肌肉中进食诱导的翻译起始刺激的发育变化。
Am J Physiol Endocrinol Metab. 2000 Dec;279(6):E1226-34. doi: 10.1152/ajpendo.2000.279.6.E1226.
8
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Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1080-7. doi: 10.1152/ajpendo.2000.279.5.E1080.
9
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway.亮氨酸通过雷帕霉素敏感途径刺激禁食大鼠骨骼肌中的翻译起始。
J Nutr. 2000 Oct;130(10):2413-9. doi: 10.1093/jn/130.10.2413.
10
Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation.口服亮氨酸可刺激禁食大鼠骨骼肌中的蛋白质合成，同时伴有真核生物翻译起始因子4F（eIF4F）形成增加。
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