Beery Susan H, Quay Herbert C, Pelham William E
1 Lycoming College, Williamsport, PA, USA.
2 University of Miami, Coral Gables, FL, USA.
J Atten Disord. 2017 Jan;21(1):62-70. doi: 10.1177/1087054712469256. Epub 2016 Jul 28.
To examine response to methylphenidate (MPH) assessed by direct observation of ecologically valid behaviors in boys with ADHD with high hyperactivity-impulsivity (HI) and those with predominantly inattentive symptoms (ADHD/I).
Sixty-three boys ages 7 to 13 participated in an ADHD Summer Treatment Program and received a double-blind placebo-controlled assessment of .3 mg/kg of MPH on problem behaviors and individualized behavior goals. Medication effect sizes were calculated for each child for each behavior.
Children with ADHD/HI ( n = 21) displayed larger MPH effect sizes for interrupting, verbal abuse, and compliance, and marginally greater response for teasing and counselor-directed goals. Children with ADHD/I ( n = 21) displayed small medication effect sizes ( ds < .20) for many behaviors often identified as primary deficits in this group (e.g., attention to activities, peer interaction, class work completion, and accuracy).
Systematic medication assessment for ADHD/I that quantifies response in ecologically valid areas of functional impairment is essential.
通过直接观察具有高度多动冲动（HI）的多动症男孩以及主要表现为注意力不集中症状（ADHD/I）的男孩的生态有效行为，来检验他们对哌甲酯（MPH）的反应。
63名7至13岁的男孩参加了一个多动症暑期治疗项目，并接受了关于0.3毫克/千克MPH对问题行为和个性化行为目标影响的双盲安慰剂对照评估。计算每个孩子每种行为的药物效应大小。
患有ADHD/HI（n = 21）的儿童在打断他人、言语攻击和顺从方面表现出更大的MPH效应大小，在戏弄和辅导员指导目标方面的反应略大。患有ADHD/I（n = 21）的儿童在许多通常被认为是该组主要缺陷的行为（如对活动的注意力、同伴互动、课堂作业完成情况和准确性）上表现出较小的药物效应大小（d值 < 0.20）。
对ADHD/I进行系统的药物评估，以量化在功能损害的生态有效领域中的反应是至关重要的。
