Department of Clinical Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Br J Psychiatry. 2013 Jan;202(1):22-7. doi: 10.1192/bjp.bp.112.112169.
Although the association between depression and excess mortality has been well established, it is not clear whether this is greater in major depression than in subthreshold depression.
To compare excess mortality in major depression with that in subthreshold depression.
We searched bibliographic databases and included prospective studies in which both major and subthreshold depression were examined at baseline and mortality was measured at follow-up.
A total of 22 studies were included. People with major depression had a somewhat increased chance of dying earlier than people with subthreshold depression but this difference was not significant, although there was a trend (relative risk 1.13, 95% CI 0.98-1.30, P = 0.1). The population attributable fraction was 7% for major depression and an additional 7% for subthreshold depression.
Although excess mortality may be somewhat higher in major than in subthreshold depression, the difference is small and the overall impact on excess mortality is comparable.
尽管抑郁症与超额死亡率之间的关联已得到充分证实，但尚不清楚这种关联在重度抑郁症中是否大于亚临床抑郁症。
比较重度抑郁症和亚临床抑郁症的超额死亡率。
我们搜索了文献数据库，并纳入了在基线检查中同时检查了重度和亚临床抑郁症，且在随访期间测量了死亡率的前瞻性研究。
共纳入了 22 项研究。与亚临床抑郁症相比，重度抑郁症患者更早死亡的几率略有增加，但这种差异并不显著，尽管存在趋势（相对风险 1.13，95%CI 0.98-1.30，P=0.1）。重度抑郁症的人群归因分数为 7%，亚临床抑郁症为 7%。
尽管重度抑郁症的超额死亡率可能略高于亚临床抑郁症，但差异很小，对超额死亡率的总体影响相当。
