• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

3-甲基-1,2,3,4,5,6,1',2',3',4'-十氢-螺[苯并[f]异喹啉-1,2'-萘并]-1'-酮

3-Methyl-1,2,3,4,5,6,1',2',3',4'-deca-hydro-spiro-[benz[f]isoquinoline-1,2'-naphthalen]-1'-one.

作者信息

Siaka Sohro, Soldatenkov Anatoly T, Malkova Anastasia V, Sorokina Elena A, Khrustalev Victor N

机构信息

Institut National Polytechnique Félix HOUPHOUËT-BOIGNY, BP 1093, Yamoussoukro, Côte d'Ivoire.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3230. doi: 10.1107/S1600536812043309. Epub 2012 Oct 27.

DOI:10.1107/S1600536812043309
PMID:23284532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3515312/
Abstract

The title compound, C(23)H(23)NO, is the product of a tandem transformation of the double Mannich base bis-(1-oxo-1,2,3,4-tertrahydro-2-naphtho-ylmeth-yl)amine hydro-chloride in HBr solution upon heating. The tetra-hydro-pyridine ring has a non-symmetrical half-chair conformation, whereas the cyclo-hexa-diene and cyclo-hexene rings adopt non-symmetrical half-boat conformations. The dihedral angle between the planes of the terminal benzene rings is 62.85 (6)°. The N atom has a trigonal-pyramidal geometry [sum of the bond angles = 332.4 (3)°]. In the crystal, mol-ecules form [001] chains via weak non-classical C-H⋯N hydrogen bonds. The chains are stacked along the b axis.

摘要

标题化合物C(23)H(23)NO是双曼尼希碱双-(1-氧代-1,2,3,4-四氢-2-萘基甲基)胺盐酸盐在HBr溶液中加热时串联转化的产物。四氢吡啶环具有不对称的半椅构象，而环己二烯环和环己烯环采用不对称的半船构象。末端苯环平面之间的二面角为62.85 (6)°。N原子具有三角锥几何形状[键角总和 = 332.4 (3)°]。在晶体中，分子通过弱的非经典C-H⋯N氢键形成[001]链。这些链沿b轴堆积。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/219a/3515312/b157f645a693/e-68-o3230-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/219a/3515312/0a37ac984d5a/e-68-o3230-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/219a/3515312/3b87614f6cab/e-68-o3230-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/219a/3515312/b157f645a693/e-68-o3230-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/219a/3515312/0a37ac984d5a/e-68-o3230-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/219a/3515312/3b87614f6cab/e-68-o3230-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/219a/3515312/b157f645a693/e-68-o3230-fig3.jpg

相似文献

1
3-Methyl-1,2,3,4,5,6,1',2',3',4'-deca-hydro-spiro-[benz[f]isoquinoline-1,2'-naphthalen]-1'-one.3-甲基-1,2,3,4,5,6,1',2',3',4'-十氢-螺[苯并[f]异喹啉-1,2'-萘并]-1'-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3230. doi: 10.1107/S1600536812043309. Epub 2012 Oct 27.
2
rac-(1S*,4aS*,8aS*)-4a-Hy-droxy-2-methyl-perhydro-spiro-[isoquinoline-4,1'-cyclo-hexa-n]-2'-one.外消旋-(1S*,4aS*,8aS*)-4a-羟基-2-甲基-全氢-螺[异喹啉-4,1'-环己烷]-2'-酮
Acta Crystallogr Sect E Struct Rep Online. 2013 Apr 5;69(Pt 5):o628. doi: 10.1107/S1600536813007010. Print 2013 May 1.
3
Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.2,7,7-三甲基-4-(1-甲基-1H-吲哚-3-基)-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸乙酯
Acta Crystallogr Sect E Struct Rep Online. 2013 Jan 1;69(Pt 1):o40-1. doi: 10.1107/S1600536812047976. Epub 2012 Dec 8.
4
Crystal structures of three 1-oxo-1,2-di-hydro-naphthalene derivatives: dimethyl 4-(4-meth-oxy-phen-yl)-2-(4-methyl-phen-yl)-1-oxo-1,2-di-hydro-naphthalene-2,3-di-carboxyl-ate, dimethyl 1-oxo-2-(pyren-4-yl)-4-(thio-phen-2-yl)-1,2-di-hydro-naphthalene-2,3-di-carboxyl-ate and ethyl 1-oxo-2-phenyl-2,4-bis-(thio-phen-2-yl)-1,2-di-hydro-naphthalene-3-carboxyl-ate.三种1-氧代-1,2-二氢萘衍生物的晶体结构：4-(4-甲氧基苯基)-2-(4-甲基苯基)-1-氧代-1,2-二氢萘-2,3-二羧酸二甲酯、1-氧代-2-(芘-4-基)-4-(噻吩-2-基)-1,2-二氢萘-2,3-二羧酸二甲酯和1-氧代-2-苯基-2,4-双(噻吩-2-基)-1,2-二氢萘-3-羧酸乙酯。
Acta Crystallogr E Crystallogr Commun. 2017 Jan 13;73(Pt 2):177-182. doi: 10.1107/S2056989017000469. eCollection 2017 Feb 1.
5
2-[(1Z)-(9-Ethyl-9H-carbazol-3-yl)methyl-eneamino]-4,5,6,7-tetra-hydro-1-benzothio-phene-3-carbonitrile-benzene (2/1).2-[(1Z)-(9-乙基-9H-咔唑-3-基亚甲基氨基)]-4,5,6,7-四氢-1-苯并噻吩-3-甲腈-苯（2/1）
Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 28;66(Pt 5):o1200-1. doi: 10.1107/S1600536810014947.
6
(E)-9-(4-Fluoro-styr-yl)-3,3,6,6-tetra-methyl-3,4,5,6,7,9-hexa-hydro-2H-xanthene-1,8-dione.（E）-9-（4-氟苯乙烯基）-3,3,6,6-四甲基-3,4,5,6,7,9-六氢-2H-呫吨-1,8-二酮
Acta Crystallogr Sect E Struct Rep Online. 2013 May 31;69(Pt 6):o985. doi: 10.1107/S1600536813014049. Print 2013 Jun 1.
7
2-(5-Bromo-pyridin-3-yl)-5-[3-(4,5,6,7-tetra-hydro-thieno[3,2-c]pyridine-5-ylsulfon-yl)thio-phen-2-yl]-1,3,4-oxa-diazole.2-(5-溴吡啶-3-基)-5-[3-(4,5,6,7-四氢噻吩并[3,2-c]吡啶-5-基磺酰基)硫代苯-2-基]-1,3,4-恶二唑
Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2743-4. doi: 10.1107/S1600536811038529. Epub 2011 Sep 30.
8
17-(Pyrimidin-2-yl)-8,16-dioxa-17-aza-tetra-cyclo-[7.7.1.0.0]hepta-deca-2,4,6,10,12,14-hexa-ene.17 -（嘧啶 - 2 - 基）- 8,16 - 二氧杂 - 17 - 氮杂 - 四环 - [7.7.1.0.0]十七碳 - 2,4,6,10,12,14 - 六烯
Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o440. doi: 10.1107/S1600536812000931. Epub 2012 Jan 18.
9
Bromination of bis-(pyridin-2-yl) diselenide in methyl-ene chloride: the reaction mechanism and crystal structures of 1-pyridine-2-selenenyl dibromide and its cyclo-adduct with cyclo-pentene (3a,9a)-2,3,3a,9a-tetra-hydro-1-cyclo-penta-[4,5][1,3]selenazolo[3,2-]pyridinium bromide.二（吡啶-2-基）二硒化物在二氯甲烷中的溴化反应：1-吡啶-2-亚硒酰基二溴化物及其与环戊烯的环加成物（3a，9a）-2，3，3a，9a-四氢-1-环戊并[4，5][1，3]硒唑并[3，2-]吡啶鎓溴化物的反应机理和晶体结构
Acta Crystallogr E Crystallogr Commun. 2019 Apr 25;75(Pt 5):675-679. doi: 10.1107/S2056989019004997. eCollection 2019 May 1.
10
Crystal structure of 10-benzyl-9-(3,4-di-meth-oxy-phen-yl)-3,3,6,6-tetra-methyl-3,4,6,7,9,10-hexa-hydro-acridine-1,8(2H,5H)-dione.10-苄基-9-(3,4-二甲氧基苯基)-3,3,6,6-四甲基-3,4,6,7,9,10-六氢吖啶-1,8(2H,5H)-二酮的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Aug 26;71(Pt 9):o688-9. doi: 10.1107/S2056989015014966. eCollection 2015 Sep 1.

引用本文的文献

1
Crystal structure and features of 3',8-di-benzyl-idene-4a,5,6,7,8,8a-hexa-hydro-2'-spiro-[chromene-2,1'-cyclo-hexa-n]-2'-one.3',8-二苄叉基-4a,5,6,7,8,8a-六氢-2'-螺[色烯-2,1'-环己烷]-2'-酮的晶体结构与特征
Acta Crystallogr E Crystallogr Commun. 2017 Oct 6;73(Pt 11):1622-1625. doi: 10.1107/S2056989017014165. eCollection 2017 Nov 1.
2
rac-(1S*,4aS*,8aS*)-4a-Hy-droxy-2-methyl-perhydro-spiro-[isoquinoline-4,1'-cyclo-hexa-n]-2'-one.外消旋-(1S*,4aS*,8aS*)-4a-羟基-2-甲基-全氢-螺[异喹啉-4,1'-环己烷]-2'-酮
Acta Crystallogr Sect E Struct Rep Online. 2013 Apr 5;69(Pt 5):o628. doi: 10.1107/S1600536813007010. Print 2013 May 1.

本文引用的文献

1
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
2
Synthesis and antiarrhythmic activity of 2-dialkylaminoalkyl-9-phenyl-1H-indeno[2,1-c]pyridine derivatives.
J Med Chem. 1978 Apr;21(4):340-3. doi: 10.1021/jm00202a005.