10'-Chloro-3',4'-dihydro-2'H-spiro-[cyclo-propane-1,7'(6'H)-pyrimido[2,1-a]isoquinolin]-6'-one.
作者信息
Okuda Kensuke, Hirota Takashi, Nishina Yuta, Ishida Hiroyuki
机构信息
Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
出版信息
Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3252. doi: 10.1107/S1600536812044261. Epub 2012 Oct 31.
Abstract
In the title compound, C(14)H(13)ClN(2)O, the fused hydro-pyrimidine ring adopts an envelope conformation with one of the methyl-ene C atoms at the flap. The three-membered ring is approximately perpendicular to the attached isoquinoline ring system, with a dihedral angle of 89.44 (11)°. In the crystal, mol-ecules are linked by a weak C-H⋯π inter-action, forming a helical chain along the c axis.
摘要
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本文引用的文献
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