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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Zoology and Physiology, University of Wyoming, Laramie.

Clin Exp Pharmacol Physiol. 1990 Feb;17(2):99-104. doi: 10.1111/j.1440-1681.1990.tb01292.x.

Isolated duodenal segments were pretreated with either of the calmodulin inhibitors proadifen or trifluoroperazine and the subsequent contractile force and frequency response to angiotensin II monitored. 2. Both proadifen and trifluoroperazine decreased the spontaneous contractile force and frequency in isolated perfused duodenal segments and attenuated the force generation following exposure to angiotensin II. Proadifen and trifluoroperazine also altered the qualitative behaviour of duodenal segments. 3. These results suggest that the action of angiotensin II on duodenal smooth muscle motility is dependent on calmodulin. Furthermore, the change in qualitative behaviour of duodenal segments following treatment with calmodulin inhibitors suggest that the function of intrinsic intestinal neurons is also altered.

分离的十二指肠段用钙调蛋白抑制剂丙胺太林或三氟拉嗪中的任一种进行预处理，随后监测对血管紧张素II的收缩力和频率反应。2. 丙胺太林和三氟拉嗪均降低了分离灌注十二指肠段的自发收缩力和频率，并减弱了暴露于血管紧张素II后的力量产生。丙胺太林和三氟拉嗪还改变了十二指肠段的定性行为。3. 这些结果表明，血管紧张素II对十二指肠平滑肌运动的作用依赖于钙调蛋白。此外，用钙调蛋白抑制剂处理后十二指肠段定性行为的变化表明，肠道内在神经元的功能也发生了改变。

Department of Zoology and Physiology, University of Wyoming, Laramie.

Clin Exp Pharmacol Physiol. 1990 Feb;17(2):99-104. doi: 10.1111/j.1440-1681.1990.tb01292.x.

Isolated duodenal segments were pretreated with either of the calmodulin inhibitors proadifen or trifluoroperazine and the subsequent contractile force and frequency response to angiotensin II monitored. 2. Both proadifen and trifluoroperazine decreased the spontaneous contractile force and frequency in isolated perfused duodenal segments and attenuated the force generation following exposure to angiotensin II. Proadifen and trifluoroperazine also altered the qualitative behaviour of duodenal segments. 3. These results suggest that the action of angiotensin II on duodenal smooth muscle motility is dependent on calmodulin. Furthermore, the change in qualitative behaviour of duodenal segments following treatment with calmodulin inhibitors suggest that the function of intrinsic intestinal neurons is also altered.

分离的十二指肠段用钙调蛋白抑制剂丙胺太林或三氟拉嗪中的任一种进行预处理，随后监测对血管紧张素II的收缩力和频率反应。2. 丙胺太林和三氟拉嗪均降低了分离灌注十二指肠段的自发收缩力和频率，并减弱了暴露于血管紧张素II后的力量产生。丙胺太林和三氟拉嗪还改变了十二指肠段的定性行为。3. 这些结果表明，血管紧张素II对十二指肠平滑肌运动的作用依赖于钙调蛋白。此外，用钙调蛋白抑制剂处理后十二指肠段定性行为的变化表明，肠道内在神经元的功能也发生了改变。