Naranjo C A, Kadlec K E, Sanhueza P, Woodley-Remus D, Sellers E M
Clinical Pharmacology Program, Addiction Research Foundation Clinical Institute, Toronto, Ontario, Canada.
Clin Pharmacol Ther. 1990 Apr;47(4):490-8. doi: 10.1038/clpt.1990.62.
The effects of fluoxetine, a relatively selective long-acting serotonin uptake inhibitor, on the consumption of alcoholic and nonalcoholic drinks, cigarette smoking, and body weight were assessed in 29 men who were early stage problem drinkers. After a 2-week baseline, subjects were randomly assigned to receive 40 mg/day fluoxetine (n = 8), 60 mg/day fluoxetine (n = 11), or placebo (n = 10) for 4 weeks. Fluoxetine 60 mg/day decreased mean daily alcoholic drinks from (X +/- SEM) 8.3 +/- 0.7 during baseline to 6.9 +/- 0.7 and decreased total drinks per 14 days from 115.8 +/- 9.3 to 96.5 +/- 9.5 (p less than 0.01; 17.3% decrease from baseline), with no significant increase in days of abstinence. Neither 40 mg/day fluoxetine nor placebo had effects on intake of alcohol. Fluoxetine 60 mg/day decreased total and mean daily alcoholic drinks compared with 40 mg/day fluoxetine (ANCOVA, both p less than 0.02), but neither dose of fluoxetine was different from placebo. Compared with placebo, both 40 mg/day fluoxetine and 60 mg/day fluoxetine no differences were detected between treatment groups, 60 mg/day fluoxetine increased mean daily nonalcoholic beverages from baseline (5.0 +/- 0.4 to 5.6 +/- 0.3, p less than 0.01) and increased daily cigarettes smoked (from 25.1 +/- 4.6 to 26.9 +/- 4.5, p less than 0.05), whereas no significant changes from baseline were observed with 40 mg/day fluoxetine or placebo.(ABSTRACT TRUNCATED AT 250 WORDS)
在29名早期有饮酒问题的男性中，评估了一种相对选择性长效血清素摄取抑制剂氟西汀对酒精饮料和非酒精饮料的摄入量、吸烟量及体重的影响。经过2周的基线期后，受试者被随机分配接受40毫克/天的氟西汀（n = 8）、60毫克/天的氟西汀（n = 11）或安慰剂（n = 10），为期4周。每天60毫克的氟西汀使平均每日酒精饮料摄入量从基线期的（X±SEM）8.3±0.7降至6.9±0.7，每14天的总饮料摄入量从115.8±9.3降至96.5±9.5（p<0.01；较基线期减少17.3%），戒酒天数无显著增加。每天40毫克的氟西汀和安慰剂对酒精摄入量均无影响。与每天40毫克的氟西汀相比，每天60毫克的氟西汀使每日酒精饮料总量和平均摄入量降低（协方差分析，p均<0.02），但两种剂量的氟西汀与安慰剂相比均无差异。与安慰剂相比，每天40毫克和60毫克的氟西汀治疗组之间未检测到差异，每天60毫克的氟西汀使平均每日非酒精饮料摄入量较基线期增加（从5.0±0.4增至5.6±0.3，p<0.01），每日吸烟量增加（从25.1±4.6增至26.9±4.5，p<0.05），而每天40毫克的氟西汀或安慰剂组与基线期相比无显著变化。（摘要截断于250字）
